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Naunyn Schmiedebergs Arch Pharmacol

Title:		Neryl butyrate induces contractile effects on isolated preparations of rat aorta
Author(s):		de Carvalho EF; Gadelha KKL; de Oliveira DMN; Lima-Silva K; Batista-Lima FJ; de Brito TS; Paula SM; da Silva MTB; Dos Santos AA; Magalhaes PJC;
Address:		"Department of Physiology and Pharmacology, Federal University of Ceara, Fortaleza, CE, Brazil. Department of Health Sciences, Rural Federal University of the Semiarid, Mossoro, RN, Brazil. Department of Physical Education, Federal University of Piaui, Teresina, PI, Brazil. Department of Physiology and Pharmacology, Federal University of Ceara, Fortaleza, CE, Brazil. pjcmagal@ufc.br. Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, R. Cel. Nunes de Melo 1315, Centro de Biomedicina, Rodolfo Teofilo, Fortaleza, CE, 60.430-270, Brazil. pjcmagal@ufc.br"
Journal Title:		Naunyn Schmiedebergs Arch Pharmacol
Year:		2020
Volume:		20190816
Issue:		1
Page Number:		43 - 55
DOI:		10.1007/s00210-019-01709-z
ISSN/ISBN:		1432-1912 (Electronic) 0028-1298 (Linking)
Abstract:		"Neryl butyrate is a constituent of volatile oils obtained from aromatic plants. Aliphatic organic compound analogues chemically close to neryl butyrate possess vasodilator properties in rat aorta. To evaluate whether neryl butyrate has relaxing properties, this study tested its effects on isolated rat aorta. Unlike the analogues, neryl butyrate did not show relaxant profile in aortic rings precontracted with phenylephrine, but induced a contraction when it stimulated aortic rings under resting tonus. The contractile effect augmented in endothelium-denuded aortic rings. Treatment of endothelium-intact preparations with the nitric oxide synthase inhibitor L-NAME or the guanylyl cyclase inhibitor ODQ also augmented the contractile effect of neryl butyrate. Such phenomenon was absent in the presence of the cyclooxygenase inhibitor indomethacin. Contractile responses decreased in the presence of verapamil, a L-type Ca(2+) channel blocker, or when Ca(2+) was removed from the extracellular solution. Antagonists of alpha-adrenergic receptors (prazosin and yohimbine), but not the thromboxane-prostanoid receptor seratrodast, reversed the contraction induced by neryl butyrate. The alpha(1A) selective antagonist RS-17053 antagonized the neryl butyrate-induced contraction. The contraction caused by neryl butyrate was decreased by inhibiting the phospholipase C or the rho-associated kinase with U-73122 or Y-27632, respectively. Injected intravenously to awake rats, neryl butyrate induced arterial hypotension and bradycardia. Decreased frequency was also present in isolated right atrium preparations. In conclusion, the contractile effects of neryl butyrate were inhibited by alpha-adrenergic antagonists, indicating the involvement of alpha-adrenoceptors in the mechanism of action. In vivo, neryl butyrate caused hypotension, suggesting that other systemic influence than vasoconstriction may occur"
Keywords:		"Adrenergic alpha-Agonists/pharmacology Amides/pharmacology Animals Aorta, Thoracic/*drug effects/physiology Butyrates/*pharmacology Calcium/pharmacology Estrenes/pharmacology Heart Atria/drug effects In Vitro Techniques Male Phenylephrine/pharmacology Pho;"
Notes:		"Medlinede Carvalho, Emanuella Feitosa Gadelha, Kalinne Kelly Lima de Oliveira, Daniel Maia Nogueira Lima-Silva, Karine Batista-Lima, Francisco Jose de Brito, Teresinha Silva Paula, Suliana Mesquita da Silva, Moises Tolentino Bento Dos Santos, Armenio Aguiar Magalhaes, Pedro Jorge Caldas eng Research Support, Non-U.S. Gov't Germany 2019/08/20 Naunyn Schmiedebergs Arch Pharmacol. 2020 Jan; 393(1):43-55. doi: 10.1007/s00210-019-01709-z. Epub 2019 Aug 16"