| Title: | Bioactive constituents of Salvia chrysophylla Stapf |
| Author(s): | Culhaoglu B; Yapar G; Dirmenci T; Topcu G; |
| Address: | "Department of Organic Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul 34469, Turkey" |
| DOI: | 10.1080/14786419.2012.734820 |
| ISSN/ISBN: | 1478-6427 (Electronic) 1478-6419 (Linking) |
| Abstract: | "The dichloromethane extract of the aerial parts of Salvia chrysophylla Stapf (Lamiaceae), which is an endemic species to south-western Anatolia, was studied for non-volatile secondary metabolites for the first time in this study. Structures of the isolated compounds were elucidated as sclareol, beta-sitosterol, salvigenin, oleanolic acid and ursolic acid. The lipid peroxidation inhibitory activity and the DPPH free radical scavenging activity of the pure isolates were investigated to establish their antioxidant potential. Their anticholinesterase activity was carried out by the Ellman assay against both enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase, and diterpene sclareol exhibited fairly good activity against both the enzymes while the two triterpenoids oleanolic and ursolic acids exhibited selective activity against AChE" |
| Keywords: | Antioxidants/chemistry Cholinesterase Inhibitors/chemistry Diterpenes/chemistry Flavones/chemistry Lamiaceae/chemistry Lipid Peroxidation/drug effects Methylene Chloride/chemistry Oleanolic Acid/chemistry Plant Extracts/chemistry Salvia/*chemistry Triterp; |
| Notes: | "MedlineCulhaoglu, Burcu Yapar, Gonul Dirmenci, Tuncay Topcu, Gulacti eng Research Support, Non-U.S. Gov't England 2012/11/07 Nat Prod Res. 2013 Mar; 27(4-5):438-47. doi: 10.1080/14786419.2012.734820. Epub 2012 Nov 6" |
