| Title: | Social Control of Hypothalamus-Mediated Male Aggression |
| Author(s): | Yang T; Yang CF; Chizari MD; Maheswaranathan N; Burke KJ; Borius M; Inoue S; Chiang MC; Bender KJ; Ganguli S; Shah NM; |
| Address: | "Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. Program in Neuroscience, UC San Francisco, San Francisco, CA 94158, USA. Department of Anatomy, UC San Francisco, San Francisco, CA 94158, USA. Program in Neuroscience, Stanford University, Stanford, CA 94305, USA. Department of Neurology, UC San Francisco, San Francisco, CA 94158, USA. Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: nirao@stanford.edu" |
| DOI: | 10.1016/j.neuron.2017.06.046 |
| ISSN/ISBN: | 1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking) |
| Abstract: | "How environmental and physiological signals interact to influence neural circuits underlying developmentally programmed social interactions such as male territorial aggression is poorly understood. We have tested the influence of sensory cues, social context, and sex hormones on progesterone receptor (PR)-expressing neurons in the ventromedial hypothalamus (VMH) that are critical for male territorial aggression. We find that these neurons can drive aggressive displays in solitary males independent of pheromonal input, gonadal hormones, opponents, or social context. By contrast, these neurons cannot elicit aggression in socially housed males that intrude in another male's territory unless their pheromone-sensing is disabled. This modulation of aggression cannot be accounted for by linear integration of environmental and physiological signals. Together, our studies suggest that fundamentally non-linear computations enable social context to exert a dominant influence on developmentally hard-wired hypothalamus-mediated male territorial aggression" |
| Keywords: | Action Potentials/drug effects/genetics Adenoviridae/genetics Aggression/*physiology Animals Antipsychotic Agents/pharmacology Clozapine/analogs & derivatives/pharmacology Cyclic Nucleotide-Gated Cation Channels/genetics/metabolism Female Hypothalamus/*cy;Neuroscience; |
| Notes: | "MedlineYang, Taehong Yang, Cindy F Chizari, M Delara Maheswaranathan, Niru Burke, Kenneth J Jr Borius, Maxim Inoue, Sayaka Chiang, Michael C Bender, Kevin J Ganguli, Surya Shah, Nirao M eng Wellcome Trust/United Kingdom R01 DA035913/DA/NIDA NIH HHS/ R01 NS049488/NS/NINDS NIH HHS/ R01 NS083872/NS/NINDS NIH HHS/ 2017/08/02 Neuron. 2017 Aug 16; 95(4):955-970.e4. doi: 10.1016/j.neuron.2017.06.046. Epub 2017 Jul 27" |
