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Nat Commun

Title:		Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans
Author(s):		Chute CD; DiLoreto EM; Zhang YK; Reilly DK; Rayes D; Coyle VL; Choi HJ; Alkema MJ; Schroeder FC; Srinivasan J;
Address:		"Biology and Biotechnology Department, Worcester Polytechnic Institute, Worcester, MA, 01605, USA. BioHelix Corporation, Beverly, MA, 01915, USA. Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA. Neurobiology Department, University of Massachusetts Medical School, Worcester, MA, 01605, USA. Instituto de Investigaciones Bioquimicas de Bahia Blanca (CONICET), Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, Bahia Blanca, B8000, Argentina. AbbVie, Cambridge, MA, 02139, USA. Biomedical Engineering Department, Worcester Polytechnic Institute, Worcester, MA, 01605, USA. Biology and Biotechnology Department, Worcester Polytechnic Institute, Worcester, MA, 01605, USA. jsrinivasan@wpi.edu"
Journal Title:		Nat Commun
Year:		2019
Volume:		20190718
Issue:		1
Page Number:		3186 -
DOI:		10.1038/s41467-019-11240-7
ISSN/ISBN:		2041-1723 (Electronic) 2041-1723 (Linking)
Abstract:		"Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily conserved. Their primary roles are in cell-to-cell signaling, as biogenic amines are not normally recruited for communication between separate individuals. Here, we show that in the nematode C. elegans, a neurotransmitter-sensing G protein-coupled receptor, TYRA-2, is required for avoidance responses to osas#9, an ascaroside pheromone that incorporates the neurotransmitter, octopamine. Neuronal ablation, cell-specific genetic rescue, and calcium imaging show that tyra-2 expression in the nociceptive neuron, ASH, is necessary and sufficient to induce osas#9 avoidance. Ectopic expression in the AWA neuron, which is generally associated with attractive responses, reverses the response to osas#9, resulting in attraction instead of avoidance behavior, confirming that TYRA-2 partakes in the sensing of osas#9. The TYRA-2/osas#9 signaling system represents an inter-organismal communication channel that evolved via co-option of a neurotransmitter and its cognate receptor"
Keywords:		"Animals Avoidance Learning/*physiology Caenorhabditis elegans/genetics/*metabolism Caenorhabditis elegans Proteins/genetics/*metabolism Cell Communication/*physiology Nociceptors/metabolism Octopamine/*metabolism Receptors, Biogenic Amine/genetics/*metabo;"
Notes:		"MedlineChute, Christopher D DiLoreto, Elizabeth M Zhang, Ying K Reilly, Douglas K Rayes, Diego Coyle, Veronica L Choi, Hee June Alkema, Mark J Schroeder, Frank C Srinivasan, Jagan eng R01 DC016058/DC/NIDCD NIH HHS/ R01 NS107475/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural England 2019/07/20 Nat Commun. 2019 Jul 18; 10(1):3186. doi: 10.1038/s41467-019-11240-7"