| Title: | Olfactory receptor for prostaglandin F2alpha mediates male fish courtship behavior |
| Author(s): | Yabuki Y; Koide T; Miyasaka N; Wakisaka N; Masuda M; Ohkura M; Nakai J; Tsuge K; Tsuchiya S; Sugimoto Y; Yoshihara Y; |
| Address: | "RIKEN Brain Science Institute, Saitama, Japan. Department of Bioengineering, Nagaoka University of Technology, Niigata, Japan. ERATO Touhara Chemosensory Signal Project, JST, The University of Tokyo, Tokyo, Japan. Brain Science Institute, Saitama University, Saitama, Japan. Department of Pharmaceutical Biochemistry, Kumamoto University Graduate School of Pharmaceutical Sciences, Kumamoto, Japan" |
| ISSN/ISBN: | 1546-1726 (Electronic) 1097-6256 (Linking) |
| Abstract: | "Pheromones play vital roles for survival and reproduction in various organisms. In many fishes, prostaglandin F2alpha acts not only as a female reproductive hormone, facilitating ovulation and spawning, but also as a sex pheromone inducing male reproductive behaviors. Here, we unravel the molecular and neural circuit mechanisms underlying the pheromonal action of prostaglandin F2alpha in zebrafish. Prostaglandin F2alpha specifically activates two olfactory receptors with different sensitivities and expression in distinct populations of ciliated olfactory sensory neurons. Pheromone information is then transmitted to two ventromedial glomeruli in the olfactory bulb and further to four regions in higher olfactory centers. Mutant male zebrafish deficient in the high-affinity receptor exhibit loss of attractive response to prostaglandin F2alpha and impairment of courtship behaviors toward female fish. These findings demonstrate the functional significance and activation of selective neural circuitry for the sex pheromone prostaglandin F2alpha and its cognate olfactory receptor in fish reproductive behavior" |
| Keywords: | "Animals Courtship Dinoprost/metabolism Olfactory Bulb/drug effects/*metabolism Olfactory Receptor Neurons/*metabolism Pheromones/metabolism Receptors, Odorant/*metabolism Receptors, Prostaglandin/*metabolism Reproduction/physiology Sexual Behavior, Animal;" |
| Notes: | "MedlineYabuki, Yoichi Koide, Tetsuya Miyasaka, Nobuhiko Wakisaka, Noriko Masuda, Miwa Ohkura, Masamichi Nakai, Junichi Tsuge, Kyoshiro Tsuchiya, Soken Sugimoto, Yukihiko Yoshihara, Yoshihiro eng Research Support, Non-U.S. Gov't 2016/05/31 Nat Neurosci. 2016 Jul; 19(7):897-904. doi: 10.1038/nn.4314. Epub 2016 May 30" |
