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Neuroimage

Title:		The smelling of Hedione results in sex-differentiated human brain activity
Author(s):		Wallrabenstein I; Gerber J; Rasche S; Croy I; Kurtenbach S; Hummel T; Hatt H;
Address:		"Department of Cell Physiology, Ruhr University Bochum, Universitatsstr. 150, 44801 Bochum, Germany. Electronic address: ivonne.wallrabenstein@rub.de. Department of Neuroradiology, Medizinische Fakultat Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr. 74, 01307 Dresden, Germany. Electronic address: johannes.gerber@uniklinikum-dresden.de. Department of Cell Physiology, Ruhr University Bochum, Universitatsstr. 150, 44801 Bochum, Germany. Electronic address: sebastian.rasche@rub.de. Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universitat Dresden, Fetscherstr. 74, 01307 Dresden, Germany. Electronic address: ilona.croy@tu-dresden.de. Department of Cell Physiology, Ruhr University Bochum, Universitatsstr. 150, 44801 Bochum, Germany. Electronic address: stefan.kurtenbach@me.com. Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universitat Dresden, Fetscherstr. 74, 01307 Dresden, Germany. Electronic address: thummel@mail.zih.tu-dresden.de. Department of Cell Physiology, Ruhr University Bochum, Universitatsstr. 150, 44801 Bochum, Germany. Electronic address: hanns.hatt@rub.de"
Journal Title:		Neuroimage
Year:		2015
Volume:		20150319
Issue:
Page Number:		365 - 373
DOI:		10.1016/j.neuroimage.2015.03.029
ISSN/ISBN:		1095-9572 (Electronic) 1053-8119 (Linking)
Abstract:		"A large family of vomeronasal receptors recognizes pheromone cues in many animals including most amphibia, reptiles, rhodents, and other mammals. Humans possess five vomeronasal-type 1 receptor genes (VN1R1-VN1R5), which code for proteins that are functional in recombinant expression systems. We used two different recombinant expression systems and identified Hedione as a ligand for the putative human pheromone receptor VN1R1 expressed in the human olfactory mucosa. Following the ligand identification, we employed functional magnetic resonance imaging (fMRI) in healthy volunteers to characterize the in vivo action of the VN1R1 ligand Hedione. In comparison to a common floral odor (phenylethyl alcohol), Hedione exhibited significantly enhanced activation in limbic areas (amygdala, hippocampus) and elicited a sex-differentiated response in a hypothalamic region that is associated with hormonal release. Utilizing a novel combination of methods, our results indicate that the putative human pheromone receptor VN1R1 is involved in extra-olfactory neuronal activations induced by the odorous substance Hedione. The activation of VN1R1 might play a role in gender-specific modulation of hormonal secretion in humans"
Keywords:		Adult Calcium Signaling/drug effects Chemotactic Factors/genetics/physiology Cyclopentanes/*pharmacology Female HEK293 Cells Humans Hypothalamus/drug effects Limbic System/drug effects Magnetic Resonance Imaging Male Olfactory Mucosa/drug effects/metaboli;Animals;
Notes:		"MedlineWallrabenstein, I Gerber, J Rasche, S Croy, I Kurtenbach, S Hummel, T Hatt, H eng Research Support, Non-U.S. Gov't 2015/03/24 Neuroimage. 2015 Jun; 113:365-73. doi: 10.1016/j.neuroimage.2015.03.029. Epub 2015 Mar 19"