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Nat Neurosci

Title:		Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium
Author(s):		Trinh K; Storm DR;
Address:		"Molecular and Cellular Biology Program and Department of Pharmacology, University of Washington, Box 357750, 1959 NE Pacific St., Seattle, Washington 98195, USA"
Journal Title:		Nat Neurosci
Year:		2003
Volume:		6
Issue:		5
Page Number:		519 - 525
DOI:		10.1038/nn1039
ISSN/ISBN:		1097-6256 (Print) 1097-6256 (Linking)
Abstract:		"It is commonly assumed that odorants are detected by the main olfactory epithelium (MOE) and pheromones are sensed through the vomeronasal organ (VNO). The complete loss of MOE-mediated olfaction in type-3 adenylyl cyclase knockout mice (AC3-/-) allowed us to examine chemosensory functions of the VNO in the absence of signaling through the MOE. Here we report that AC3-/- mice are able to detect certain volatile odorants via the VNO. These same odorants elicited electro-olfactogram transients in the VNO and MOE of wild-type mice, but only VNO responses in AC3-/- mice. This indicates that some odorants are detected through an AC3-independent pathway in the VNO"
Keywords:		"Adenylyl Cyclases/deficiency/genetics Animals Isoenzymes/deficiency/genetics Mice Mice, Knockout *Odorants Olfactory Mucosa/drug effects/*physiology Signal Transduction/drug effects/*physiology Smell/drug effects/*physiology Vomeronasal Organ/drug effects;"
Notes:		"MedlineTrinh, Kien Storm, Daniel R eng DC04156/DC/NIDCD NIH HHS/ HL07312-22/HL/NHLBI NIH HHS/ T32 GMO7270/GM/NIGMS NIH HHS/ Comparative Study Research Support, U.S. Gov't, P.H.S. 2003/04/01 Nat Neurosci. 2003 May; 6(5):519-25. doi: 10.1038/nn1039"