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Clin Transl Gastroenterol

Title:		Detecting Colorectal Adenomas and Cancer Using Volatile Organic Compounds in Exhaled Breath: A Proof-of-Principle Study to Improve Screening
Author(s):		Cheng HR; van Vorstenbosch RWR; Pachen DM; Meulen LWT; Straathof JWA; Dallinga JW; Jonkers D; Masclee AAM; Schooten FV; Mujagic Z; Smolinska A;
Address:		"Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands. Department of Gastroenterology and Hepatology, Maxima Medical Center, Veldhoven, the Netherlands. GROW, School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands. NUTRIM, School of Nutrition & Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands. Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands"
Journal Title:		Clin Transl Gastroenterol
Year:		2022
Volume:		20221101
Issue:		11
Page Number:		e00518 -
DOI:		10.14309/ctg.0000000000000518
ISSN/ISBN:		2155-384X (Electronic) 2155-384X (Linking)
Abstract:		"INTRODUCTION: Early detection of colorectal cancer (CRC) by screening programs is crucial because survival rates worsen at advanced stages. However, the currently used screening method, the fecal immunochemical test (FIT), suffers from a high number of false-positives and is insensitive for detecting advanced adenomas (AAs), resulting in false-negatives for these premalignant lesions. Therefore, more accurate, noninvasive screening tools are needed. In this study, the utility of analyzing volatile organic compounds (VOCs) in exhaled breath in a FIT-positive population to detect the presence of colorectal neoplasia was studied. METHODS: In this multicenter prospective study, breath samples were collected from 382 FIT-positive patients with subsequent colonoscopy participating in the national Dutch bowel screening program (n = 84 negative controls, n = 130 non-AAs, n = 138 AAs, and n = 30 CRCs). Precolonoscopy exhaled VOCs were analyzed using thermal desorption-gas chromatography-mass spectrometry, and the data were preprocessed and analyzed using machine learning techniques. RESULTS: Using 10 discriminatory VOCs, AAs could be distinguished from negative controls with a sensitivity and specificity of 79% and 70%, respectively. Based on this biomarker profile, CRC and AA combined could be discriminated from controls with a sensitivity and specificity of 77% and 70%, respectively, and CRC alone could be discriminated from controls with a sensitivity and specificity of 80% and 70%, respectively. Moreover, the feasibility to discriminate non-AAs from controls and AAs was shown. DISCUSSION: VOCs in exhaled breath can detect the presence of AAs and CRC in a CRC screening population and may improve CRC screening in the future"
Keywords:		Humans *Volatile Organic Compounds/analysis Early Detection of Cancer/methods Prospective Studies *Adenoma/diagnosis/pathology *Colorectal Neoplasms/diagnosis/pathology;
Notes:		"MedlineCheng, Hao Ran van Vorstenbosch, Robert W R Pachen, Danielle M Meulen, Lonne W T Straathof, Jan Willem A Dallinga, Jan W Jonkers, Daisy M A E Masclee, Ad A M Schooten, Frederik-Jan van Mujagic, Zlatan Smolinska, Agnieszka eng Multicenter Study Research Support, Non-U.S. Gov't 2022/08/19 Clin Transl Gastroenterol. 2022 Nov 1; 13(11):e00518. doi: 10.14309/ctg.0000000000000518"