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Mol Cell Biol


Title:A position effect on the expression of a tRNA gene mediated by the SIR genes in Saccharomyces cerevisiae
Author(s):Schnell R; Rine J;
Address:
Journal Title:Mol Cell Biol
Year:1986
Volume:6
Issue:2
Page Number:494 - 501
DOI: 10.1128/mcb.6.2.494-501.1986
ISSN/ISBN:0270-7306 (Print) 1098-5549 (Electronic) 0270-7306 (Linking)
Abstract:The SIR genes of Saccharomyces cerevisiae are responsible for the position-dependent regulation of the a and alpha mating-type genes. Previous work by others has shown that the products of the SIR genes prevent the accumulation of stable transcripts of the a and alpha genes at HML and HMR. Results of this study establish that this regulation is a region-specific effect rather than a gene-specific effect since expression of a tRNA gene placed at HMR is repressed by the products of the SIR genes
Keywords:"DNA Restriction Enzymes *Genes, Fungal *Genes, Mating Type, Fungal *Genes, Regulator Genotype Mating Factor Nucleic Acid Hybridization Peptides/genetics Phenotype Plasmids RNA, Transfer/*genetics Saccharomyces cerevisiae/*genetics;"
Notes:"MedlineSchnell, R Rine, J eng GM31105/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1986/02/01 Mol Cell Biol. 1986 Feb; 6(2):494-501. doi: 10.1128/mcb.6.2.494-501.1986"

 
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