| Title: | Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue |
| Author(s): | Chen Y; Getchell ML; Ding X; Getchell TV; |
| Address: | "Division of Otolaryngology-Head and Neck Surgery, University of Kentucky College of Medicine, Lexington 40536" |
| DOI: | 10.1097/00001756-199209000-00007 |
| ISSN/ISBN: | 0959-4965 (Print) 0959-4965 (Linking) |
| Abstract: | "The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/pheromone clearance, a perireceptor process associated with chemosensory transduction" |
| Keywords: | "Animals Cytochrome P-450 Enzyme System/*analysis Isoenzymes/*analysis Mucous Membrane/enzymology Nasal Mucosa/*enzymology Nasal Septum/*enzymology Olfactory Mucosa/*enzymology Organ Specificity/physiology Rats Rats, Sprague-Dawley Respiratory System/enzym;" |
| Notes: | "MedlineChen, Y Getchell, M L Ding, X Getchell, T V eng DC-00159/DC/NIDCD NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. England 1992/09/01 Neuroreport. 1992 Sep; 3(9):749-52. doi: 10.1097/00001756-199209000-00007" |
