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Neuron

Title:		A presynaptic gain control mechanism fine-tunes olfactory behavior
Author(s):		Root CM; Masuyama K; Green DS; Enell LE; Nassel DR; Lee CH; Wang JW;
Address:		"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA"
Journal Title:		Neuron
Year:		2008
Volume:		59
Issue:		2
Page Number:		311 - 321
DOI:		10.1016/j.neuron.2008.07.003
ISSN/ISBN:		1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking)
Abstract:		"Early sensory processing can play a critical role in sensing environmental cues. We have investigated the physiological and behavioral function of gain control at the first synapse of olfactory processing in Drosophila. Olfactory receptor neurons (ORNs) express the GABA(B) receptor (GABA(B)R), and its expression expands the dynamic range of ORN synaptic transmission that is preserved in projection neuron responses. Strikingly, each ORN channel has a unique baseline level of GABA(B)R expression. ORNs that sense the aversive odorant CO(2) do not express GABA(B)Rs and do not have significant presynaptic inhibition. In contrast, pheromone-sensing ORNs express a high level of GABA(B)Rs and exhibit strong presynaptic inhibition. Furthermore, pheromone-dependent mate localization is impaired in flies that lack GABA(B)Rs in specific ORNs. These findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs"
Keywords:		"Animals Animals, Genetically Modified Behavior, Animal/*physiology Drosophila Proteins/physiology Drosophila melanogaster Female Olfactory Pathways/physiology Olfactory Receptor Neurons/*physiology Presynaptic Terminals/*physiology Receptors, GABA-B/physi;"
Notes:		"MedlineRoot, Cory M Masuyama, Kaoru Green, David S Enell, Lina E Nassel, Dick R Lee, Chi-Hon Wang, Jing W eng R01 DC009597/DC/NIDCD NIH HHS/ R01 DC009597-01/DC/NIDCD NIH HHS/ R01DC009597/DC/NIDCD NIH HHS/ Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2008/08/01 Neuron. 2008 Jul 31; 59(2):311-21. doi: 10.1016/j.neuron.2008.07.003"