| Title: | Volatile fingerprints of cancer specific genetic mutations |
| Author(s): | Peled N; Barash O; Tisch U; Ionescu R; Broza YY; Ilouze M; Mattei J; Bunn PA; Hirsch FR; Haick H; |
| Address: | "Thoracic Cancer Research and Detection Center, Sheba Medical Center, Tel-Hashomer, Tel Aviv, Israel" |
| DOI: | 10.1016/j.nano.2013.01.008 |
| ISSN/ISBN: | 1549-9642 (Electronic) 1549-9634 (Print) 1549-9634 (Linking) |
| Abstract: | "We report on a new concept for profiling genetic mutations of (lung) cancer cells, based on the detection of patterns of volatile organic compounds (VOCs) emitted from cell membranes, using an array of nanomaterial-based sensors. In this in-vitro pilot study we have derived a volatile fingerprint assay for representative genetic mutations in cancer cells that are known to be associated with targeted cancer therapy. Five VOCs were associated with the studied oncogenes, using complementary chemical analysis, and were discussed in terms of possible metabolic pathways. The reported approach could lead to the development of novel methods for guiding treatments, so that patients could benefit from safer, more timely and effective interventions that improve survival and quality of life while avoiding unnecessary invasive procedures. Studying clinical samples (tissue/blood/breath) will be required as next step in order to determine whether this cell-line study can be translated into a clinically useful tool. FROM THE CLINICAL EDITOR: In this novel study, a new concept for profiling genetic mutations of (lung) cancer cells is described, based on the detection of patterns of volatile organic compounds emitted from cell membranes, using an array of nano-gold based sensors" |
| Keywords: | "*Biosensing Techniques DNA Fingerprinting ErbB Receptors/genetics Humans Lung Neoplasms/diagnosis/*genetics/pathology Mutation Nanostructures/chemistry Oncogene Proteins, Fusion/genetics Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins p21(ras) Vo;" |
| Notes: | "MedlinePeled, Nir Barash, Orna Tisch, Ulrike Ionescu, Radu Broza, Yoav Y Ilouze, Maya Mattei, Jane Bunn, Paul A Jr Hirsch, Fred R Haick, Hossam eng P50 CA058187/CA/NCI NIH HHS/ P50 CA 058187/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2013/02/23 Nanomedicine. 2013 Aug; 9(6):758-66. doi: 10.1016/j.nano.2013.01.008. Epub 2013 Feb 18" |
