| Title: | Quorum sensing signal-response systems in Gram-negative bacteria |
| Address: | "Department of Biology, Ludwig-Maximilians-University Munich, Biocenter, 82152 Martinsried, Germany. Howard Hughes Medical Institute; Department of Molecular Biology, 329 Lewis Thomas Laboratories, Washington Road, Princeton University, Princeton, New Jersey 08544, USA" |
| ISSN/ISBN: | 1740-1534 (Electronic) 1740-1526 (Print) 1740-1526 (Linking) |
| Abstract: | "Bacteria use quorum sensing to orchestrate gene expression programmes that underlie collective behaviours. Quorum sensing relies on the production, release, detection and group-level response to extracellular signalling molecules, which are called autoinducers. Recent work has discovered new autoinducers in Gram-negative bacteria, shown how these molecules are recognized by cognate receptors, revealed new regulatory components that are embedded in canonical signalling circuits and identified novel regulatory network designs. In this Review we examine how, together, these features of quorum sensing signal-response systems combine to control collective behaviours in Gram-negative bacteria and we discuss the implications for host-microbial associations and antibacterial therapy" |
| Keywords: | Anti-Bacterial Agents/pharmacology Bacterial Proteins/metabolism Gram-Negative Bacteria/chemistry/genetics/*physiology Pheromones/chemistry/*metabolism *Quorum Sensing Signal Transduction; |
| Notes: | "MedlinePapenfort, Kai Bassler, Bonnie L eng HHMI_/Howard Hughes Medical Institute/ R01 GM065859/GM/NIGMS NIH HHS/ R37 GM065859/GM/NIGMS NIH HHS/ Review England 2016/08/12 Nat Rev Microbiol. 2016 Aug 11; 14(9):576-88. doi: 10.1038/nrmicro.2016.89" |
