| Title: | N-acyl homoserine lactone-producing Pseudomonas putida strain T2-2 from human tongue surface |
| Author(s): | Chen JW; Chin S; Tee KK; Yin WF; Choo YM; Chan KG; |
| Address: | "Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. kokgan@um.edu.my" |
| ISSN/ISBN: | 1424-8220 (Electronic) 1424-8220 (Linking) |
| Abstract: | "Bacterial cell-to-cell communication (quorum sensing) refers to the regulation of bacterial gene expression in response to changes in microbial population density. Quorum sensing bacteria produce, release and respond to chemical signal molecules called autoinducers. Bacteria use two types of autoinducers, namely autoinducer-1 (AI-1) and autoinducer-2 (AI-2) where the former are N-acylhomoserine lactones and the latter is a product of the luxS gene. Most of the reported literatures show that the majority of oral bacteria use AI-2 for quorum sensing but rarely the AI-1 system. Here we report the isolation of Pseudomonas putida strain T2-2 from the oral cavity. Using high resolution mass spectrometry, it is shown that this isolate produced N-octanoylhomoserine lactone (C8-HSL) and N-dodecanoylhomoserine lactone (C12-HSL) molecules. This is the first report of the finding of quorum sensing of P. putida strain T2-2 isolated from the human tongue surface and their quorum sensing molecules were identified" |
| Keywords: | 4-Butyrolactone/*analogs & derivatives/metabolism Humans Pheromones/*metabolism Pseudomonas putida/classification/*isolation & purification/*physiology Quorum Sensing/*physiology Species Specificity Tongue/*microbiology; |
| Notes: | "MedlineChen, Jian-Woon Chin, Shenyang Tee, Kok Keng Yin, Wai-Fong Choo, Yeun Mun Chan, Kok-Gan eng Research Support, Non-U.S. Gov't Switzerland 2013/10/03 Sensors (Basel). 2013 Sep 30; 13(10):13192-203. doi: 10.3390/s131013192" |
