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Neuro Endocrinol Lett

Title:		Phosphorylation of cAMP response element-binding protein in the extended amygdala of male rats is induced by novel environment and attenuated by estrous female-bedding
Author(s):		Nishitani S; Funabashi T; Shinohara K; Kimura F;
Address:		"Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
Journal Title:		Neuro Endocrinol Lett
Year:		2013
Volume:		34
Issue:		2
Page Number:		118 - 123
DOI:
ISSN/ISBN:		0172-780X (Print) 0172-780X (Linking)
Abstract:		"OBJECTIVE: We examined whether female pheromone, which would be contained in female-soiled bedding, affected the expression of phosphorylated cAMP response element-binding protein-like (pCREB) immunoreactive cells in the extended amygdala. METHODS: Male rats were exposed to following conditions: maintained in their home cage (home cage group), or relocated to a cage containing clean bedding (clean-bedding exposed group), ovariectomized (OVX) rat-soiled bedding (OVX-bedding exposed group) or estrogen-treated OVX rat-soiled bedding (OVX+E2-bedding exposed group). Rats were sacrificed 10-20 min after exposure and brain sections were subject to immunocytochemical processing. RESULTS: In the medial subdivision of the bed nucleus of the stria terminalis (BST) and the central amygdala (CeA), the number of pCREB immunoreactive (pCREB-ir) cells in the clean-bedding exposed group was significantly larger than in the home cage group, while the number of pCREB-ir cells in the OVX+E2-bedding exposed group did not differ from that in the home cage group. The bedding soiled by OVX rats was less effective. No significant difference in the number of pCREB-ir cells was detected in the other regions of the extended amygdala among all groups. CONCLUSIONS: The present study suggests that the exposure of clean bedding to male rats induces the expression of pCREB-ir in the medial BST and the CeA; exposure to female pheromone attenuates this expression"
Keywords:		"Amygdala/*metabolism Animals Brain/metabolism Cyclic AMP Response Element-Binding Protein/*metabolism Estrogens/*metabolism Female Male Neurons/metabolism Phosphorylation Proto-Oncogene Proteins c-fos/*metabolism Rats Rats, Wistar;"
Notes:		"MedlineNishitani, Shota Funabashi, Toshiya Shinohara, Kazuyuki Kimura, Fukuko eng Research Support, Non-U.S. Gov't Sweden 2013/05/07 Neuro Endocrinol Lett. 2013; 34(2):118-23"