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Molecules

Title:		Volatiles and Antifungal-Antibacterial-Antiviral Activity of South African Salvia spp. Essential Oils Cultivated in Uniform Conditions
Author(s):		Najar B; Mecacci G; Nardi V; Cervelli C; Nardoni S; Mancianti F; Ebani VV; Giannecchini S; Pistelli L;
Address:		"Department of Pharmacy, University of Pisa, Via Bonanno Pisano 33, 56126 Pisa, Italy. Council for Agricultural Research and Economics (CREA), Corso Inglesi 508, 18038 Sanremo, Italy. Department of Veterinary Sciences, University of Pisa, Viale delle Piagge 2, 56124 Pisa, Italy. Interdepartmental Research Center 'Nutraceutical and Food for Health', University of Pisa, Via del Borghetto, 80, 56126 Pisa, Italy. Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 48, 50134 Florence, Italy"
Journal Title:		Molecules
Year:		2021
Volume:		20210510
Issue:		9
Page Number:		-
DOI:		10.3390/molecules26092826
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Spontaneous emissions of S. dentata Aiton and S. scabra Thunb., as well as the essential oil (EO) composition of the cited species, together with S. aurea L., were investigated. The chemical profile of the first two species is reported here for the first time. Moreover, in vitro tests were performed to evaluate the antifungal activity of these EOs on Trichophyton mentagrophytes, Microsporum canis, Aspergillus flavus, Aspergillus niger, and Fusarium solani. Secondly, the EO antibacterial activity against Escherichia coli, Staphylococcus aureus, and Staphylococcus pseudointermedius was examined, and their antiviral efficacy against the H1N1 influenza virus was assessed. Leaf volatile organic compounds (VOCs), as well as the EOs obtained from the arial part of Salvia scabra, were characterized by a high percentage of sesquiterpene hydrocarbons (97.8% and 76.6%, respectively), mostly represented by an equal amount of germacrene D (32.8% and 32.7%, respectively). Both leaf and flower spontaneous emissions of S. dentata, as well as the EO composition, showed a prevalence of monoterpenes divided into a more or less equal amount of hydrocarbon and oxygenated compounds. Interestingly, its EO had a non-negligible percentage of oxygenated sesquiterpenes (29.5%). S. aurea EO, on the contrary, was rich in sesquiterpenes, both hydrocarbons and oxygenated compounds (41.5% and 33.5%, respectively). S. dentata EO showed good efficacy (Minimal Inhibitory Concentration (MIC): 0.5%) against M. canis. The tested EOs were not active against E. coli and S. aureus, whereas a low inhibition of S. dentata EO was observed on S. pseudointermedius (MIC = 10%). Once again, S. dentata EO showed a very good H1N1 inhibition; contrariwise, S. aurea EO was completely inactive against this virus. The low quantity of S. scabra EO made it impossible to test its biological activity. S. dentata EO exhibited interesting new perspectives for medicinal and industrial uses"
Keywords:		"Anti-Bacterial Agents/*pharmacology Antifungal Agents/*pharmacology Bacteria/drug effects Flowers/chemistry Fungi/drug effects Microbial Sensitivity Tests Odorants Oils, Volatile/*pharmacology Plant Leaves/chemistry Salvia/*chemistry Volatile Organic Comp;"
Notes:		"MedlineNajar, Basma Mecacci, Giulia Nardi, Valeria Cervelli, Claudio Nardoni, Simona Mancianti, Francesca Ebani, Valentina Virginia Giannecchini, Simone Pistelli, Luisa eng Switzerland 2021/06/03 Molecules. 2021 May 10; 26(9):2826. doi: 10.3390/molecules26092826"