| Title: | "Potential effect of maternal dietary sucrose or fructose syrup on CD36, leptin, and ghrelin-mediated fetal programming of obesity" |
| Author(s): | Kisioglu B; Nergiz-Unal R; |
| Address: | "Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Sihhiye 06100, Ankara, Turkey" |
| DOI: | 10.1080/1028415X.2018.1491151 |
| ISSN/ISBN: | 1476-8305 (Electronic) 1028-415X (Linking) |
| Abstract: | "The influence of HFCS (high fructose corn syrup - free fructose) and sucrose (bound fructose) on fetal appetite signals is unknown. This study aimed to determine the effects of HFCS or sucrose on the peptide-mediated appetite regulation in fetal programming of obesity. Sprague Dawley female rats were administered feed and plain water (control) or water containing maltodextrin (vehicle), sucrose, fructose, or HFCS (20%, w/v) for 12 weeks before mating and throughout pregnancy and lactation (n(dams) = 31; n(pups) = 207). Maternal chow-feed consumption in the HFCS and sucrose groups and sugar-added drink consumption in the HFCS group were higher compared to the vehicle and control groups (P < 0.05). The total body fat accumulated in sucrose, fructose, and HFCS groups in dams and pups was higher than those in the vehicle and control groups (P < 0.05). The HFCS groups showed lower plasma leptin levels and higher ghrelin levels. Soluble CD36 levels in plasma and tongue samples were high in HFCS groups of dams and pups (P < 0.05). Rather than bound fructose, the free fructose from the maternal diet contributes to the programming of obesity through the disruption of leptin, ghrelin, and CD36 expression involved in appetite regulation" |
| Keywords: | Animals Appetite Regulation/physiology CD36 Antigens/analysis/*physiology Dietary Sucrose/administration & dosage Dietary Sugars/*administration & dosage Female Fetal Development/*physiology Fructose/administration & dosage Ghrelin/blood/*physiology Lepti; |
| Notes: | "MedlineKisioglu, Betul Nergiz-Unal, Reyhan eng England 2018/07/03 Nutr Neurosci. 2020 Mar; 23(3):210-220. doi: 10.1080/1028415X.2018.1491151. Epub 2018 Jul 1" |
