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FEBS Lett

Title:		"Yeast ABC transporters-- a tale of sex, stress, drugs and aging"
Author(s):		Jungwirth H; Kuchler K;
Address:		"Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, Campus Vienna Biocenter, Austria"
Journal Title:		FEBS Lett
Year:		2006
Volume:		20051222
Issue:		4
Page Number:		1131 - 1138
DOI:		10.1016/j.febslet.2005.12.050
ISSN/ISBN:		0014-5793 (Print) 0014-5793 (Linking)
Abstract:		"Yeast ATP-binding cassette (ABC) proteins are implicated in many biological phenomena, often acting at crossroads of vital cellular processes. Their functions encompass peptide pheromone secretion, regulation of mitochondrial function, vacuolar detoxification, as well as pleiotropic drug resistance and stress adaptation. Because yeast harbors several homologues of mammalian ABC proteins with medical importance, understanding their molecular mechanisms, substrate interaction and three-dimensional structure of yeast ABC proteins might help identifying new approaches aimed at combating drug resistance or other ABC-mediated diseases. This review provides a comprehensive discussion on the functions of the ABC protein family in the yeast Saccharomyces cerevisiae"
Keywords:		"ATP-Binding Cassette Transporters/chemistry/genetics/metabolism/*physiology Gene Expression Regulation, Fungal Protein Conformation Saccharomyces cerevisiae/*metabolism Saccharomyces cerevisiae Proteins/*metabolism;"
Notes:		"MedlineJungwirth, Helmut Kuchler, Karl eng Research Support, Non-U.S. Gov't Review England 2006/01/13 FEBS Lett. 2006 Feb 13; 580(4):1131-8. doi: 10.1016/j.febslet.2005.12.050. Epub 2005 Dec 22"