| Title: | Sustained human chemosignal unconsciously alters brain function |
| Author(s): | Jacob S; Kinnunen LH; Metz J; Cooper M; McClintock MK; |
| Address: | "Institute for Mind and Biology, University of Chicago, 5730 South Woodlawn Avenue, Chicago, IL 60637, USA" |
| DOI: | 10.1097/00001756-200108080-00021 |
| ISSN/ISBN: | 0959-4965 (Print) 0959-4965 (Linking) |
| Abstract: | "The human chemosignal, Delta 4,16-androstadien-3-one modulates psychological state without being consciously discernible as an odor. This study demonstrates that Delta 4,16-androstadien-3-one (androstadienone) alters cerebral glucose utilization both in subcortical regions and in areas of the neocortex not exclusively associated with olfaction. These widely distributed changes are consistent with modulation of an integrated neural network for regulation of emotional and attentional states. This is the first study to demonstrate the effects of a sustained chemosignal on brain metabolism and to show that they are similar to those of long acting chemical substances that affect psychological states. Moreover, this provides the first evidence that a human chemosignal has distributed effects on cortical processes and brain metabolism even when it is not detected consciously" |
| Keywords: | "Adult *Androstenedione Attention/*physiology Awareness/physiology Brain/*physiology Emotions/physiology Female Glucose/metabolism Humans Odorants Pheromones Smell/*physiology Tomography, Emission-Computed;" |
| Notes: | "MedlineJacob, S Kinnunen, L H Metz, J Cooper, M McClintock, M K eng HD-07009/HD/NICHD NIH HHS/ R37 MH41788/MH/NIMH NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 2001/08/10 Neuroreport. 2001 Aug 8; 12(11):2391-4. doi: 10.1097/00001756-200108080-00021" |
