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Neuroscience

Title:		Parallel Olfactory Systems Synergistically Activate the Posteroventral Part of the Medial Amygdala Upon Alarm Pheromone Detection in Rats
Author(s):		Kobayashi-Sakashita M; Kiyokawa Y; Takeuchi Y;
Address:		"Laboratory of Veterinary Ethology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. Laboratory of Veterinary Ethology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address: akiyo@mail.ecc.u-tokyo.ac.jp"
Journal Title:		Neuroscience
Year:		2023
Volume:		20230428
Issue:
Page Number:		123 - 133
DOI:		10.1016/j.neuroscience.2023.04.019
ISSN/ISBN:		1873-7544 (Electronic) 0306-4522 (Linking)
Abstract:		"In rats, a mixture of hexanal and 4-methylpentanal is a main component of the alarm pheromone. When detected by the main olfactory system (MOS) and the vomeronasal system, respectively, they activate the anterior part of the bed nucleus of the stria terminalis (BNSTa). Therefore, the information from the two olfactory systems is expected to be integrated before being transmitted to the BNSTa. To specify the integration site, we examined Fos expression in 16 brain regions in response to water (n = 10), hexanal (n = 9), 4-methylpentanal (n = 9), the mixture (n = 9), or the alarm pheromone (n = 9) in male rats. The posteroventral part of the medial amygdala showed increased Fos expression to hexanal and 4-methylpentanal. The expression was further increased by the mixture. Therefore, this region is suggested as the integration site. In addition, the BNSTa, paraventricular nucleus of the hypothalamus, and anteroventral, anterodorsal, and posterodorsal parts of the medial amygdala were suggested to be located downstream of the integrated site because only the mixture increased Fos expression. We suggest that the posterolateral part of the cortical amygdala is upstream of the integration site in the MOS because all stimuli increased Fos expression. The posterior part of the bed nucleus of the stria terminalis and posteromedial part of the cortical amygdala were suggested as being located upstream in the vomeronasal system because 4-methylpentanal and the mixture increased Fos expression. These results provide information about the neural pathway underlying the alarm pheromone effects"
Keywords:		Rats Male Animals *Pheromones/metabolism *Brain/metabolism Amygdala/metabolism Proto-Oncogene Proteins c-fos/metabolism alarm pheromone anxiety olfactory system social behavior;
Notes:		"MedlineKobayashi-Sakashita, Mao Kiyokawa, Yasushi Takeuchi, Yukari eng 2023/05/01 Neuroscience. 2023 Jun 15; 521:123-133. doi: 10.1016/j.neuroscience.2023.04.019. Epub 2023 Apr 28"