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« Previous AbstractRegulatory mechanisms underlying pheromone biosynthesis activating neuropeptide (PBAN)-induced internalization of the Bombyx mori PBAN receptor    Next AbstracttRNA genes as transcriptional repressor elements »

Biosci Biotechnol Biochem


Title:"Sex pheromone production in the silkworm, Bombyx mori, is mediated by store-operated Ca2+ channels"
Author(s):Hull JJ; Kajigaya R; Imai K; Matsumoto S;
Address:"Molecular Entomology Laboratory, RIKEN, Wako, Saitama, Japan. joeh@postman.riken.go.jp"
Journal Title:Biosci Biotechnol Biochem
Year:2007
Volume:20070807
Issue:8
Page Number:1993 - 2001
DOI: 10.1271/bbb.70175
ISSN/ISBN:0916-8451 (Print) 0916-8451 (Linking)
Abstract:"In most female moths, pheromone biosynthesis activating neuropeptide (PBAN) regulates sex pheromone production by stimulating an influx of extracellular Ca(2+). Little is known about the plasma membrane channel or how the PBAN stimulus is communicated to the channel. Fluorescent Ca(2+) imaging techniques confirmed PBAN-induced Ca(2+) influx in the silkworm, Bombyx mori, and showed that the PBAN response is reduced with repeated stimulation. Compounds known to impact Ca(2+) signaling were examined for their effects on sex pheromone production. These experiments demonstrated that the PBAN signal is likely mediated by a store-operated channel (SOC). SOC blockers, SKF-96365 and 2-aminoethoxydiphenyl borate, abolished sex pheromone production, as did flufenamic acid, a blocker of transient receptor potential (TRP) channels. Thapsigargin mimicked the pheromonotropic effects of PBAN. Similar results were seen when PBAN-induced lipase activity was assayed. Conversely, 1-oleoyl-2-acetyl-sn-glycerol and arachidonic acid, activators of diacylglycerol-dependent Ca(2+) channels, had no effect on bombykol production"
Keywords:Animals Bombyx Calcium Channel Agonists/pharmacology Calcium Channel Blockers/pharmacology Calcium Channels/*physiology Calcium Signaling/physiology Female Neuropeptides/*physiology Sex Attractants/*biosynthesis;
Notes:"MedlineHull, J Joe Kajigaya, Ryosuke Imai, Kiyohiro Matsumoto, Shogo eng Research Support, Non-U.S. Gov't England 2007/08/11 Biosci Biotechnol Biochem. 2007 Aug; 71(8):1993-2001. doi: 10.1271/bbb.70175. Epub 2007 Aug 7"

 
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Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
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