| Title: | "Preparation, In Vitro and In Vivo Evaluation of Nanoemulsion In Situ Gel for Transnasal Delivery of Traditional Chinese Medicine Volatile Oil from Ligusticum sinense Oliv.cv. Chaxiong" |
| Author(s): | Huang C; Wang C; Zhang W; Yang T; Xia M; Lei X; Peng Y; Wu Y; Feng J; Li D; Zhang G; |
| Address: | "Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330006, China. Wuzhou Traditional Chinese Medicine Hospital, Wuzhou 543001, China. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China. National Engineering Research Center of Chinese Medicine Solid Preparation Manufacturing Technology, Nanchang 330006, China. College of Chinese Medicine and Life Science, Jiangxi University of Chinese Medicine, Nanchang 330004, China" |
| DOI: | 10.3390/molecules27217644 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Ischemic stroke is a difficult-to-treat brain disease that may be attributed to a limited therapeutic time window and lack of effective clinical drugs. Nasal-brain administration is characterized by low systemic toxicity and is a direct and non-invasive brain targeting route. Preliminary studies have shown that the volatile oil of Chaxiong (VOC) has an obvious anti-ischemic stroke effect. In this work, we designed a nanoemulsion thermosensitive in situ gel (VOC-NE-ISG) loaded with volatile oil of Chaxiong for ischemia via intranasal delivery to rat brain treatment of cerebral ischemic stroke. The developed VOC-NE-ISG formulation has a suitable particle size of 21.02 +/- 0.25 nm and a zeta potential of -20.4 +/- 1.47 mV, with good gelling ability and prolonged release of the five components of VOC. The results of in vivo pharmacokinetic studies and brain targeting studies showed that intranasal administration of VOC-NE-ISG could significantly improve the bioavailability and had excellent brain-targeting efficacy of nasal-to-brain delivery. In addition, the results of pharmacodynamics experiments showed that both VOC-NE and VOC-NE-ISG could reduce the neurological deficit score of model rats, reducing the size of cerebral infarction, with a significant effect on improving ischemic stroke. Overall, VOC-NE-ISG may be a promising intranasal nanomedicine for the effective treatment of ischemic stroke" |
| Keywords: | "Animals Rats *Ligusticum Medicine, Chinese Traditional *Oils, Volatile/pharmacology *Volatile Organic Compounds/pharmacology Gels/pharmacology Administration, Intranasal Particle Size Brain *Stroke Emulsions/pharmacology *Nanoparticles in situ gel nanoemu;" |
| Notes: | "MedlineHuang, Chunhui Wang, Canjian Zhang, Wenliu Yang, Tao Xia, Mingyan Lei, Xiaomeng Peng, Ying Wu, Yuhuan Feng, Jianfang Li, Dongxun Zhang, Guosong eng 2021BSZR014/Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program, Nanchang high level scientific and technological innovation talents " double hundred plan" project, Jiangxi University of Chinese Medicine Doctoral Research/ 81960720/the National Natural Science Foundation of China/ 202111/WT_/Wellcome Trust/United Kingdom Switzerland 2022/11/12 Molecules. 2022 Nov 7; 27(21):7644. doi: 10.3390/molecules27217644" |
