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Nature

Title:		A regulatory hierarchy for cell specialization in yeast
Author(s):		Herskowitz I;
Address:		"Department of Biochemistry and Biophysics, University of California, San Francisco 94143"
Journal Title:		Nature
Year:		1989
Volume:		342
Issue:		6251
Page Number:		749 - 757
DOI:		10.1038/342749a0
ISSN/ISBN:		0028-0836 (Print) 0028-0836 (Linking)
Abstract:		The specialized sets of genes that determine different cell types in yeast are controlled by combinations of DNA-binding proteins some of which are present only in certain cell types whereas others are present in all cell types. Final differentiation requires an inductive signal that triggers both gene transcription and cell-cycle arrest. Synthesis of the proteins coded by the 'master regulatory' mating-type locus is regulated so as to generate a heterogeneous mitotic cell population containing a stem-cell lineage
Keywords:		"Fungal Proteins/genetics GTP-Binding Proteins/physiology *Gene Expression Regulation, Fungal Genes, Fungal Mating Factor Peptides/physiology Protein Kinases/physiology Saccharomyces cerevisiae/*cytology/genetics Signal Transduction Transcription Factors/p;"
Notes:		"MedlineHerskowitz, I eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review England 1989/12/14 Nature. 1989 Dec 14; 342(6251):749-57. doi: 10.1038/342749a0"