| Title: | Perceptive costs of reproduction drive ageing and physiology in male Drosophila |
| Author(s): | Harvanek ZM; Lyu Y; Gendron CM; Johnson JC; Kondo S; Promislow DEL; Pletcher SD; |
| Address: | "Department of Molecular &Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA. Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan 48109, USA. Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan. Department of Pathology, University of Washington, Seattle, Washington 98195, USA. Department of Biology, University of Washington, Seattle, Washington 98195, USA. Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA" |
| ISSN/ISBN: | 2397-334X (Electronic) 2397-334X (Linking) |
| Abstract: | "Costs of reproduction are thought to result from natural selection optimizing organismal fitness within putative physiological constraints. Phenotypic and population genetic studies of reproductive costs are plentiful across taxa, but an understanding of their mechanistic basis would provide important insight into the diversity in life-history traits, including reproductive effort and ageing. Here, we dissect the causes and consequences of specific costs of reproduction in male Drosophila melanogaster. We find that key survival and physiological costs of reproduction arise from perception of the opposite sex, and they are reversed by the act of mating. In the absence of pheromone perception, males are free from reproductive costs on longevity, stress resistance and fat storage. The costs of perception and the benefits of mating are both mediated by evolutionarily conserved neuropeptidergic signalling molecules, as well as the transcription factor dFoxo. These results provide a molecular framework in which certain costs of reproduction arise as a result of self-imposed 'decisions' in response to perceptive neural circuits, which then orchestrate the control of life-history traits independently of physical or energetic effects associated with mating itself" |
| Notes: | "PubMed-not-MEDLINEHarvanek, Zachary M Lyu, Yang Gendron, Christi M Johnson, Jacob C Kondo, Shu Promislow, Daniel E L Pletcher, Scott D eng R01 GM102279/GM/NIGMS NIH HHS/ R01 AG030593/AG/NIA NIH HHS/ T32 GM008322/GM/NIGMS NIH HHS/ R37 AG051649/AG/NIA NIH HHS/ R01 AG051649/AG/NIA NIH HHS/ R01 AG049494/AG/NIA NIH HHS/ F30 AG048661/AG/NIA NIH HHS/ England 2017/08/16 Nat Ecol Evol. 2017 May 15; 1(6):152. doi: 10.1038/s41559-017-0152" |
