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Otolaryngol Head Neck Surg

Title:		Volatile Organic Compounds in the Breath of Oral Squamous Cell Carcinoma Patients: A Pilot Study
Author(s):		Hartwig S; Raguse JD; Pfitzner D; Preissner R; Paris S; Preissner S;
Address:		"1 Department of Oral and Maxillofacial Surgery/Clinical Navigation, Charite-Universitatsmedizin Berlin, Berlin, Germany. 3 Department of Operative and Preventive Dentistry, Charite-Universitatsmedizin Berlin, Berlin, Germany. 2 Institute of Physiology, Structural Bioinformatics Group, Charite-Universitatsmedizin Berlin, Berlin, Germany"
Journal Title:		Otolaryngol Head Neck Surg
Year:		2017
Volume:		20170606
Issue:		6
Page Number:		981 - 987
DOI:		10.1177/0194599817711411
ISSN/ISBN:		1097-6817 (Electronic) 0194-5998 (Linking)
Abstract:		"Objective To assess the feasibility of detecting signature volatile organic compounds in the breath of patients with oral squamous cell carcinoma. Study Design Prospective cohort pilot study. Setting University hospital. Subjects and Methods Using gas chromatography and mass spectrometry, emitted volatile organic compounds in the breath of patients before and after curative surgery (n = 10) were compared with those of healthy subjects (n = 4). It was hypothesized that certain volatile organic compounds disappear after surgical therapy. A characteristic signature of these compounds for diseased patients was compiled and validated. Results Breath analyses revealed 125 volatile organic compounds in patients with oral cancer. A signature of 8 compounds that were characteristic for patients with oral cancer could be detected: 3 from this group presented were absent after surgery. Conclusion The presented results confirmed the hypothesis of an absence of cancer-associated volatile organic compounds in the breath after therapy. In this pilot study, we proved the feasibility of this test approach. Further studies should be initiated to establish protocols for usage in a clinical setting"
Keywords:		"Adolescent Adult Aged Biomarkers, Tumor/analysis Breath Tests Carcinoma, Squamous Cell/diagnosis/*metabolism/surgery Feasibility Studies Female Gas Chromatography-Mass Spectrometry Humans Male Middle Aged Mouth Neoplasms/diagnosis/*metabolism/surgery Oral;"
Notes:		"MedlineHartwig, Stefan Raguse, Jan D Pfitzner, Dorothee Preissner, Robert Paris, Sebastian Preissner, Saskia eng Clinical Trial Research Support, Non-U.S. Gov't England 2017/06/07 Otolaryngol Head Neck Surg. 2017 Dec; 157(6):981-987. doi: 10.1177/0194599817711411. Epub 2017 Jun 6"