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Neuroreport

Title:		Urine and urine-derived compounds induce c-fos mRNA expression in accessory olfactory bulb
Author(s):		Guo J; Zhou A; Moss RL;
Address:		"Department of Texas Southwestern Medical Center, Dallas 75235, USA"
Journal Title:		Neuroreport
Year:		1997
Volume:		8
Issue:		7
Page Number:		1679 - 1683
DOI:		10.1097/00001756-199705060-00024
ISSN/ISBN:		0959-4965 (Print) 0959-4965 (Linking)
Abstract:		"Soiled bedding from male mice induced c-fos mRNA expression in the accessory olfactory bulb (AOB) and main olfactory bulb (MOB) of female mice. The increase observed in the AOB, but not the MOB, was dependent on the presence of the vomeronasal organ (VNO). Male urine alone also increased c-fos mRNA expression in the AOB. The urine-derived compounds dehydro-exo-brevicomin (DHB) and sec-butyl-dihydrothiazole (SBT) in combination with major urinary protein (MUP) induced significantly greater c-fos mRNA expression in the AOB than in the MOB. The results indicate that compounds derived from male urine are detected at the AOB and suggest that specific urinary compounds play an important role in AOB-mediated reproductive events"
Keywords:		"Alpha-Globulins/analysis/physiology Amygdala/drug effects/metabolism Animals Autoradiography Blotting, Northern Bridged Bicyclo Compounds, Heterocyclic/analysis/pharmacology Female Male Mice Mice, Inbred C57BL Mice, Inbred ICR Olfactory Bulb/*drug effects;"
Notes:		"MedlineGuo, J Zhou, A Moss, R L eng DC02120/DC/NIDCD NIH HHS/ MH41784/MH/NIMH NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1997/05/06 Neuroreport. 1997 May 6; 8(7):1679-83. doi: 10.1097/00001756-199705060-00024"