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Science

Title:		A pheromone influences larval development in the nematode Caenorhabditis elegans
Author(s):		Golden JW; Riddle DL;
Address:
Journal Title:		Science
Year:		1982
Volume:		218
Issue:		4572
Page Number:		578 - 580
DOI:		10.1126/science.6896933
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"A Caenorhabditis-specific pheromone and the food supply influence both entry into and exit from a developmentally arrested juvenile stage called the dauer larva. The pheromone increases the frequency of dauer larva formation and inhibits recovery but does not affect adult behavior such as chemotaxis and egg laying. The fatty acid--like pheromone has been partially purified and characterized by a new bioassay. If similar developmental control mechanisms are used by parasitic nematodes, such mechanisms might be exploited to develop highly selective anthelmintic agents"
Keywords:		"Animals Behavior, Animal/physiology Caenorhabditis/*growth & development Environment Fatty Acids/physiology Female Food Deprivation Larva Oviposition Pheromones/*physiology;"
Notes:		"MedlineGolden, J W Riddle, D L eng GM07494/GM/NIGMS NIH HHS/ HD00367/HD/NICHD NIH HHS/ HD11239/HD/NICHD NIH HHS/ etc. Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1982/11/05 Science. 1982 Nov 5; 218(4572):578-80. doi: 10.1126/science.6896933"