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Nature

Title:		TRP channels as cellular sensors
Author(s):		Clapham DE;
Address:		"Howard Hughes Medical Institute, Pediatric Cardiology, Children's Hospital of Boston, Department of Neurobiology, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA. dclapham@enders.tch.harvard.edu"
Journal Title:		Nature
Year:		2003
Volume:		426
Issue:		6966
Page Number:		517 - 524
DOI:		10.1038/nature02196
ISSN/ISBN:		1476-4687 (Electronic) 0028-0836 (Linking)
Abstract:		"TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell"
Keywords:		"Animals Calcium/metabolism Calcium Channels/chemistry/genetics/*metabolism Cells/*metabolism Humans Ion Channel Gating *Models, Biological *Signal Transduction TRPC Cation Channels;"
Notes:		"MedlineClapham, David E eng Review England 2003/12/05 Nature. 2003 Dec 4; 426(6966):517-24. doi: 10.1038/nature02196"