| Title: | WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour |
| Author(s): | Chen SL; Liu BT; Lee WP; Liao SB; Deng YB; Wu CL; Ho SM; Shen BX; Khoo GH; Shiu WC; Chang CH; Shih HW; Wen JK; Lan TH; Lin CC; Tsai YC; Tzeng HF; Fu TF; |
| Address: | "Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan. Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan. Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan. Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan. Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu, Taiwan. National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan. Department of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan. Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan. Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan. yctsaibio@thu.edu.tw. Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan. hftzeng@ncnu.edu.tw. Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan. tffu@ncnu.edu.tw" |
| DOI: | 10.1038/s41467-022-30165-2 |
| ISSN/ISBN: | 2041-1723 (Electronic) 2041-1723 (Linking) |
| Abstract: | "The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABA(A) receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour" |
| Keywords: | "Acetates Animals Courtship Drosophila/metabolism *Drosophila Proteins/genetics/metabolism Drosophila melanogaster/metabolism Endocrine System/metabolism *Insulins Male Perception Pheromones Receptors, GABA-A Sexual Behavior, Animal/physiology;Animals;Neuroscience;" |
| Notes: | "MedlineChen, Shiu-Ling Liu, Bo-Ting Lee, Wang-Pao Liao, Sin-Bo Deng, Yao-Bang Wu, Chia-Lin Ho, Shuk-Man Shen, Bing-Xian Khoo, Guan-Hock Shiu, Wei-Chiang Chang, Chih-Hsuan Shih, Hui-Wen Wen, Jung-Kun Lan, Tsuo-Hung Lin, Chih-Chien Tsai, Yu-Chen Tzeng, Huey-Fen Fu, Tsai-Feng eng Research Support, Non-U.S. Gov't England 2022/05/07 Nat Commun. 2022 May 6; 13(1):2518. doi: 10.1038/s41467-022-30165-2" |
