« Previous AbstractOn the Use of Permselectivity to Describe the Selective Transfer of Organic Acids in Electrodialysis    Next AbstractSubstitution of carcinogenic solvent dichloromethane for the extraction of volatile compounds in a fat-free model food system »

Nucl Med Commun

Title:		Scintigraphic evaluation of renal functional damage in volatile substance abusers
Author(s):		Cayir D; Demirel K; Korkmaz M; Araz M; Koca G;
Address:		"aDepartment of Nuclear Medicine, Diskapi Yildirim Beyazit Training and Research Hospital bDepartment of Nuclear Medicine, Ankara Training and Research Hospital, Ankara, Turkey"
Journal Title:		Nucl Med Commun
Year:		2016
Volume:		37
Issue:		6
Page Number:		623 - 631
DOI:		10.1097/MNM.0000000000000490
ISSN/ISBN:		1473-5628 (Electronic) 0143-3636 (Linking)
Abstract:		"OBJECTIVE: Volatile organic compounds can be maintained easily and can cause dependency. Volatile substance abuse may cause damage by affecting several systems. The aim of our study was to evaluate renal functional damage in volatile substance abusers by diuretic renogram. METHODS: Twenty nine volatile substance abusers and 30 young healthy voluntary young men were included in our study. Technetium-99m mertiatide diuretic renogram was used to evaluate renal functions and collective system urodynamics to investigate the progress of renal functional damage. Images were evaluated visually and quantitatively. Split renal function of each kidney, time to peak activity (Tmax), and half-time for radiopharmaceutical clearance from pelvicalyceal system (T1/2), ratio of cortical and whole-kidney counts at 20-3 min, and maximum counts (T20/3 and T20/max) were compared in the two groups. RESULTS: In the study group, time to reach peak activity was statistically prolonged compared with the healthy volunteers. In the volatile substance abuser group, the average Tmax values, average T1/2 values, cortical and whole-kidney T20/3, and T20/max values were found to be prolonged compared with the control group in the diuretic renogram. There was no significant difference in the split renal function ratios between the two groups. CONCLUSION: In this study, possible renal functional damage was evaluated in volatile substance abusers by diuretic renogram. In conclusion, diuretic renogram can be useful in the evaluation of renal functional damage before blood renal function tests are affected and it could be used in the follow-up of the disease in volatile substance abusers. The results of this pilot study from our country, of course, should be supported by further clinical studies"
Keywords:		"Acute Kidney Injury/*chemically induced/*diagnostic imaging/physiopathology Adult Aerosols/poisoning Diuretics Humans Image Interpretation, Computer-Assisted/*methods Kidney Function Tests/*methods Male Radioisotope Renography/methods Radionuclide Imaging;"
Notes:		"MedlineCayir, Derya Demirel, Koray Korkmaz, Meliha Araz, Mine Koca, Gokhan eng Randomized Controlled Trial England 2016/02/18 Nucl Med Commun. 2016 Jun; 37(6):623-31. doi: 10.1097/MNM.0000000000000490"