| Title: | Simple coupling of gas chromatography to electrospray ionization mass spectrometry |
| Author(s): | Brenner N; Haapala M; Vuorensola K; Kostiainen R; |
| Address: | "Division of Pharmaceutical Chemistry, Faculty of Pharmacy, P.O. Box 56, FI-00014 University of Helsinki, Finland" |
| ISSN/ISBN: | 1520-6882 (Electronic) 0003-2700 (Linking) |
| Abstract: | "A simple method for direct coupling of gas chromatography (GC) with electrospray ionization mass spectrometry (ESI/MS) has been developed. The outlet of the GC capillary column was placed between the ESI needle and the atmospheric pressure ionization (API) source of a mass spectrometer. The ionization occurs via dissolution of neutral compounds into the charged ESI droplet followed by ion evaporation or via a gas-phase proton transfer reaction between a protonated solvent molecule and an analyte. The mass spectra of organic volatile compounds showed abundant protonated molecules with little fragmentation, being very similar to those produced by normal liquid ESI. The quantitative performance of the system was evaluated by determining the limit of detection (LOD), linearity ( r (2)), and repeatability (RSD). The GC-ESI/MS method was shown to be stable, providing high sensitivity and good quantitative performance" |
| Keywords: | "Gas Chromatography-Mass Spectrometry/*methods Molecular Structure Spectrometry, Mass, Electrospray Ionization/*methods;" |
| Notes: | "MedlineBrenner, Nina Haapala, Markus Vuorensola, Katariina Kostiainen, Risto eng 2008/10/08 Anal Chem. 2008 Nov 1; 80(21):8334-9. doi: 10.1021/ac801406t. Epub 2008 Oct 7" |
