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J Fungi (Basel)

Title:		Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1
Author(s):		Cai E; Sun S; Deng Y; Huang P; Sun X; Wang Y; Chang C; Jiang Z;
Address:		"College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Integrate Microbiology Research Center, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China. Environmental Monitoring and Remediation Engineering Technology Research Center, School of Environmental Engineering, Yellow River Conservancy Technical Institute, Kaifeng 475004, China"
Journal Title:		J Fungi (Basel)
Year:		2021
Volume:		20210728
Issue:		8
Page Number:		-
DOI:		10.3390/jof7080610
ISSN/ISBN:		2309-608X (Electronic) 2309-608X (Linking)
Abstract:		"Many prokaryotes and eukaryotes utilize two-component signaling pathways to counter environmental stress and regulate virulence genes associated with infection. In this study, we identified and characterized a conserved histidine kinase (SsSln1), which is the sensor of the two-component system of Sln1-Ypd1-Ssk1 in Sporisorium scitamineum. SsSln1 null mutant exhibited enhanced mating and virulence capabilities in S. scitamineum, which is opposite to what has been reported in Candida albicans. Further investigations revealed that the deletion of SsSLN1 enhanced SsHog1 phosphorylation and nuclear localization and thus promoted S. scitamineum mating. Interestingly, SsSln1 and cAMP/PKA signaling pathways antagonistically regulated the transcription of pheromone-responsive transcription factor SsPrf1, for regulating S. scitamineum mating and virulence. In short, the study depicts a novel mechanism in which the cross-talk between SsSln1 and cAMP/PKA pathways antagonistically regulates mating and virulence by balancing the transcription of the SsPRF1 gene in S. scitamineum"
Keywords:		Sporisorium scitamineum cAMP/PKA cross-talk histidine kinase Sln1 mating;
Notes:		"PubMed-not-MEDLINECai, Enping Sun, Shuquan Deng, Yizhen Huang, Peishen Sun, Xian Wang, Yuting Chang, Changqing Jiang, Zide eng 2020B0202090001/the Key Realm R&D Program of Guang Dong Province/ 2021A1515011101/the Natural Science Foundation of Guangdong Province/ 201904020010/Key Projects of Guangzhou Science and Technology Plan/ Switzerland 2021/08/27 J Fungi (Basel). 2021 Jul 28; 7(8):610. doi: 10.3390/jof7080610"