| Title: | Sensing the environment: lessons from fungi |
| Author(s): | Bahn YS; Xue C; Idnurm A; Rutherford JC; Heitman J; Cardenas ME; |
| Address: | "Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea" |
| ISSN/ISBN: | 1740-1534 (Electronic) 1740-1526 (Linking) |
| Abstract: | "All living organisms use numerous signal-transduction systems to sense and respond to their environments and thereby survive and proliferate in a range of biological niches. Molecular dissection of these signalling networks has increased our understanding of these communication processes and provides a platform for therapeutic intervention when these pathways malfunction in disease states, including infection. Owing to the expanding availability of sequenced genomes, a wealth of genetic and molecular tools and the conservation of signalling networks, members of the fungal kingdom serve as excellent model systems for more complex, multicellular organisms. Here, we review recent progress in our understanding of how fungal-signalling circuits operate at the molecular level to sense and respond to a plethora of environmental cues" |
| Keywords: | "*Adaptation, Physiological Ammonia/analysis/metabolism Animals Carbon Dioxide/analysis/metabolism Fungi/*physiology Glucose/analysis/metabolism Humans Light Mycoses/microbiology Pheromones/analysis/metabolism Plants/microbiology *Signal Transduction;" |
| Notes: | "MedlineBahn, Yong-Sun Xue, Chaoyang Idnurm, Alexander Rutherford, Julian C Heitman, Joseph Cardenas, Maria E eng R01 CA114107/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England 2006/12/16 Nat Rev Microbiol. 2007 Jan; 5(1):57-69. doi: 10.1038/nrmicro1578" |
