« Previous AbstractPenicillium expansum volatiles reduce pine weevil attraction to host plants    Next AbstractVapor-phase testing of the memory-effects in benzene- and toluene-imprinted polymers conditioned at elevated temperature »

Niger J Physiol Sci

Title:		Safety Evaluation of Osun River Water Containing Heavy Metals and Volatile Organic Compounds (VOCs) in Rats
Author(s):		Azeez L; Salau AK; Adewuyi SO; Osineye SO; Tijani KO; Balogun RO;
Address:		"Environmental, Analytical and Nutritional Chemistry Research Laboratory, Department of Chemical Sciences, Osun State University, Osogbo. azeez012000@yahoo.com"
Journal Title:		Niger J Physiol Sci
Year:		2015
Volume:		20151220
Issue:		1-Feb
Page Number:		103 - 109
DOI:
ISSN/ISBN:		0794-859X (Print) 0794-859X (Linking)
Abstract:		"This study evaluated the pH, heavy metals and volatile organic compounds (VOCs) in Osun river water. It also evaluated its safety in rats. Heavy metals were determined by atomic absorption spectrophotometry (AAS) while VOCs were determined by gas chromatography coupled with flame ionization detector (GC-FID). Male and female rats were exposed to Osun river water for three weeks and then sacrificed. The abundance of heavy metals in Osun river followed the trend Pb > Cd > Zn > Fe > Cr > Cu while VOCs followed the trend benzene < ethylbenzene < toluene < xylene. The concentrations of Pb, Cd and benzene were higher than the permissible limits of Standards Organization of Nigeria (SON) and World Health Organization (WHO) respectively. Rats exposed to Osun river water for three weeks had increased WBC, thiobarbituric acid reactive substances (TBARS), serum proteins and serum aminotransferases. There were also significant decreases in HCT, PLT, liver aminotransferases and liver glutathione compared to the control. These results show that the pollutants in Osun river water are capable of inducing hematological imbalance and liver cell injury. The toxicity induced in blood was sex-dependent affecting female rats more than male rats"
Keywords:		"Animals Chemical Safety/*standards Female Liver/chemistry/metabolism Male Metals, Heavy/*analysis/blood/metabolism Nigeria/epidemiology Rats Rats, Wistar Rivers/*chemistry Volatile Organic Compounds/*analysis/blood/metabolism Water Pollutants, Chemical/*a;"
Notes:		"MedlineAzeez, L Salau, A K Adewuyi, S O Osineye, S O Tijani, K O Balogun, R O eng Nigeria 2015/01/01 Niger J Physiol Sci. 2015 Dec 20; 30(1-2):103-9"