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Science

Title:		Olfactory recognition: a simple memory system
Author(s):		Brennan P; Kaba H; Keverne EB;
Address:		"Sub-Department of Animal Behaviour, University of Cambridge, United Kingdom"
Journal Title:		Science
Year:		1990
Volume:		250
Issue:		4985
Page Number:		1223 - 1226
DOI:		10.1126/science.2147078
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Mice have an olfactory (pheromone) recognition memory located at the first relay in the sensory system. It is acquired with one-trial learning, contingent upon norepinephrine activation at mating, and lasts for several weeks. The mechanism involves Hebbian (association-dependent) changes in synaptic efficacy at dendrodendritic synapses in the accessory olfactory bulb. As a result of this memory, males made familiar by mating are recognized by the females, thereby mitigating pregnancy block. Such a memory function is biologically important to the female, as it is required to sustain pregnancy in the presence of her stud male's odors"
Keywords:		"Amygdala/drug effects/physiology Animals Female Hypothalamus/physiology Lidocaine/pharmacology Male Memory/*physiology Mice Mice, Inbred BALB C Mice, Inbred CBA N-Methylaspartate/antagonists & inhibitors/physiology Norepinephrine/physiology Olfactory Bulb;"
Notes:		"MedlineBrennan, P Kaba, H Keverne, E B eng Research Support, Non-U.S. Gov't 1990/11/30 Science. 1990 Nov 30; 250(4985):1223-6. doi: 10.1126/science.2147078"