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Neuroreport

Title:		Effect of urine-derived compounds on cAMP accumulation in mouse vomeronasal cells
Author(s):		Zhou A; Moss RL;
Address:		"Department of Physiology, University of Texas Southwestern Medical Center at Dallas 75235-9040, USA"
Journal Title:		Neuroreport
Year:		1997
Volume:		8
Issue:		9-Oct
Page Number:		2173 - 2177
DOI:		10.1097/00001756-199707070-00017
ISSN/ISBN:		0959-4965 (Print) 0959-4965 (Linking)
Abstract:		"Urine-derived compounds from the male mouse altered the levels of the second messenger molecule cAMP differentially in female mouse vomeronasal (VN) cells when compared with olfactory cilia. cAMP levels in VN cells increased after exposure to forskolin and GTP-gamma-S, while the levels decreased after exposure to the urine-derived compounds, dehydro-exo-brevicomin (DHB) and 2-(sec-butyl)-4, 5-dihydrothiazole (SBT), in a dose-dependent manner. The general odorant citronellal did not alter cAMP levels. In contrast DHB, SBT and citronellal increased cAMP levels in olfactory cilia. We concluded that urine-derived compounds exert a differential effect on cAMP accumulation in mammalian VN and olfactory receptor neurons"
Keywords:		"Acyclic Monoterpenes Aldehydes/*pharmacology Animals Bridged Bicyclo Compounds, Heterocyclic/*pharmacology Cyclic AMP/*metabolism Dose-Response Relationship, Drug Female Male Mice Mice, Inbred ICR *Monoterpenes Olfactory Receptor Neurons/drug effects Pher;"
Notes:		"MedlineZhou, A Moss, R L eng R01 DC 02120/DC/NIDCD NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1997/07/07 Neuroreport. 1997 Jul 7; 8(9-10):2173-7. doi: 10.1097/00001756-199707070-00017"