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Zoolog Sci

Title:		Appeasing pheromone inhibits cortisol augmentation and agonistic behaviors during social stress in adult miniature pigs
Author(s):		Yonezawa T; Koori M; Kikusui T; Mori Y;
Address:		"Department of Veterinary Physiology, the Universiyt of Tokyo, Tokyo, Japan. yonezawa@vmas.kitasato-u.ac.jp"
Journal Title:		Zoolog Sci
Year:		2009
Volume:		26
Issue:		11
Page Number:		739 - 744
DOI:		10.2108/zsj.26.739
ISSN/ISBN:		0289-0003 (Print) 0289-0003 (Linking)
Abstract:		"Pairing and physical confrontation In adult sows causes social stress reactions and aggressive behaviors. Recently, maternal pig skin secretions were Isolated and a mixture containing several fatty acids, now called pig appeasing pheromone (PAP), was synthesized. In this study, we Investigated the effects of PAP on social and Immune stress response In adult female miniature pigs. PAP or vehicle solvents were sprayed Into the pens of Individually housed adult sows. A two-week exposure to the pheromone did not alter basal salivary Cortisol levels or clrcadlan rhythms. Following this treatment, the animals were paired and placed In a new pen that was divided with a wire-mesh fence. Although salivary cortisol Increased markedly In the vehicle-treated group, the PAP-treated group exhibited a drastic Inhibition of cortisol secretion. This effect was sustained even after they were allowed to physically Interact following fence removal. Moreover, the latency time of agonistic behaviors, such as escaping or biting, was significantly extended after PAP exposure. When lipopolysaccharide was Injected Intramuscularly, Cortisol levels, rectal temperatures, and lying time lengths Increased substantially. No differences were observed between the pheromone-treated and untreated groups. These results suggest that this synthetic pheromone alleviates social stress In adult pigs, although It does not affect Immune stress responses. Our findings demonstrate the potential benefit of this pheromone In field applications and clinical disciplines relating to adult female pigs"
Keywords:		"Aggression/*drug effects Animals Female Housing, Animal Hydrocortisone/analysis/*metabolism Lipopolysaccharides Pheromones/*pharmacology Saliva/chemistry *Stress, Psychological Swine *Swine, Miniature;"
Notes:		"MedlineYonezawa, Tomohiro Koori, Miyuki Kikusui, Takefumi Mori, Yuji eng Controlled Clinical Trial Research Support, Non-U.S. Gov't Japan 2009/11/03 Zoolog Sci. 2009 Nov; 26(11):739-44. doi: 10.2108/zsj.26.739"