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J Agric Food Chem

Title:		Changes in acaricidal potency by introducing functional radicals and an acaricidal constituent isolated from Schizonepeta tenuifolia
Author(s):		Yang JY; Lee HS;
Address:		"Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Science, Chonbuk National University , Jeonju 561-756, Republic of Korea"
Journal Title:		J Agric Food Chem
Year:		2013
Volume:		20131115
Issue:		47
Page Number:		11511 - 11516
DOI:		10.1021/jf404586k
ISSN/ISBN:		1520-5118 (Electronic) 0021-8561 (Linking)
Abstract:		"The acaricidal potential of an active constituent isolated from Schizonepeta tenuifolia oil and its structurally related derivatives was evaluated using filter paper and impregnated cotton fabric disk bioassays against house dust and stored food mites. The acaricidal constituent of S. tenuifolia oil was isolated by chromatographic techniques and identified as 2-isopropyl-5-methylcyclohexanone by GC-MS, (1)H-, and (13)C NMR spectra. 2-Isopropyl-5-methylcyclohexanone was a potent acaricide against house dust and stored food mites, based on the LD50 values from the filter paper and impregnated cotton fabric disk bioassays, followed by 4-isopropylcyclohexanone, 2-isopropylidene-5-methylcyclohexanone, 2-methylcyclohexanone, 3-methylcyclohexanone, 4-methylcyclohexanone, and benzyl benzoate. Furthermore, 4-isopropylcyclohexanone and 2-isopropyl-5-methylcyclohexanone, which were introduced on the isopropyl (C3H7) functional radical of the cyclohexanone skeleton, had the highest acaricidal potency. These results indicate that S. tenuifolia oil and 2-isopropyl-5-methylcyclohexanone structural analogues could be effective natural acaricides for managing house dust and stored food mites"
Keywords:		"Acaricides/*chemistry/*pharmacology Animals Cyclohexanones/chemistry/*pharmacology Drug Evaluation, Preclinical/methods Gossypium Lamiaceae/*chemistry Lethal Dose 50 Mites/drug effects Molecular Structure Plant Oils/chemistry Structure-Activity Relationsh;"
Notes:		"MedlineYang, Ji-Yeon Lee, Hoi-Seon eng Research Support, Non-U.S. Gov't 2013/11/12 J Agric Food Chem. 2013 Nov 27; 61(47):11511-6. doi: 10.1021/jf404586k. Epub 2013 Nov 15"