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Neuron

Title:		Control of the postmating behavioral switch in Drosophila females by internal sensory neurons
Author(s):		Yang CH; Rumpf S; Xiang Y; Gordon MD; Song W; Jan LY; Jan YN;
Address:		"Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA"
Journal Title:		Neuron
Year:		2009
Volume:		61
Issue:		4
Page Number:		519 - 526
DOI:		10.1016/j.neuron.2008.12.021
ISSN/ISBN:		1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking)
Abstract:		"Mating induces changes in the receptivity and egg-laying behavior in Drosophila females, primarily due to a peptide pheromone called sex peptide which is transferred with the sperm into the female reproductive tract during copulation. Whereas sex peptide is generally believed to modulate fruitless-GAL4-expressing neurons in the central nervous system to produce behavioral changes, we found that six to eight sensory neurons on the reproductive tract labeled by both ppk-GAL4 and fruitless-GAL4 can sense sex peptide to control the induction of postmating behaviors. In these sensory neurons, sex peptide appears to act through Pertussis toxin-sensitive G proteins and suppression of protein kinase A activity to reduce synaptic output. Our results uncover a neuronal mechanism by which sex peptide exerts its control over reproductive behaviors in Drosophila females"
Keywords:		"Animals Cloning, Molecular Cyclic AMP-Dependent Protein Kinases/physiology Drosophila/*physiology Drosophila Proteins/genetics/physiology Enzyme Activation/physiology Female Heterotrimeric GTP-Binding Proteins/genetics/physiology Immunohistochemistry Male;"
Notes:		"MedlineYang, Chung-Hui Rumpf, Sebastian Xiang, Yang Gordon, Michael D Song, Wei Jan, Lily Y Jan, Yuh-Nung eng R01 NS040929-08/NS/NINDS NIH HHS/ R37 NS040929/NS/NINDS NIH HHS/ R01 NS40929/NS/NINDS NIH HHS/ HHMI/Howard Hughes Medical Institute/ R37 MH065334-28/MH/NIMH NIH HHS/ R01 NS040929/NS/NINDS NIH HHS/ R37 MH065334/MH/NIMH NIH HHS/ R01 MH084234/MH/NIMH NIH HHS/ R01 NS040929-07/NS/NINDS NIH HHS/ R37 MH065334-29/MH/NIMH NIH HHS/ R01 NS040929-09/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2009/03/03 Neuron. 2009 Feb 26; 61(4):519-26. doi: 10.1016/j.neuron.2008.12.021"