| Title: | The Effect of Ginger Juice Processing on the Chemical Profiles of Rhizoma coptidis |
| Author(s): | Yang C; Guo F; Zang C; Li C; Cao H; Zhang B; |
| Address: | "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. yangchunyu314@163.com. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Fengqianguo@126.com. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. czang@icmm.ac.cn. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. licui198209@126.com. School of Pharmacy, Jinan University, Guangzhou 510632, China. kovhuicao@aliyun.com. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhangbaoxian925@tom.com" |
| DOI: | 10.3390/molecules23020380 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Rhizoma coptidis (RC) has been used as an herbal medicine in China for over one thousand years, and it was subjected to specific processing before use as materia medica. Processing is a pharmaceutical technique that aims to enhance the efficacy and/or reduce the toxicity of crude drugs according to traditional Chinese medicine theory. In this study, the chemical profiles of RC, ginger juice processed RC (GRC), and water processed RC (WRC) was determined to reveal the mechanism of processing of RC. UPLC-QTOF-MS analysis of methanol extract of RC, GRC, and WRC has been conducted to investigate the effect of processing on the composition of RC. HPLC-PDA was used to determine the variance of total alkaloids and seven alkaloids of RC during the processing. The volatiles of RC, GRC and ginger juice were separated by distillation, the change of volatiles content was recorded and analyzed, and the qualitative analysis of the volatiles was carried out using GC-MS. The microstructures of RC, GRC and WRC were observed using a light microscope. Results showed that ginger juice/water processing had limited influence on the composition of RC's methanol extract, but significant influence on the content of some alkaloids in RC. Ginger juice processing significantly increased (p < 0.05) the volatiles content of RC and changed the volatiles composition obviously. Processing also had an influence on the microstructure of RC. This research comprehensively revealed the mechanism of ginger juice processing of RC" |
| Keywords: | "Alkaloids/chemistry Chromatography, High Pressure Liquid Coptis chinensis Drugs, Chinese Herbal/*chemistry Flavoring Agents/analysis/chemistry Ginger/*chemistry Molecular Structure Volatile Organic Compounds/*analysis Rhizoma coptidis alkaloid giner juice;" |
| Notes: | "MedlineYang, Chunyu Guo, Fengqian Zang, Chen Li, Cui Cao, Hui Zhang, Baoxian eng Switzerland 2018/02/15 Molecules. 2018 Feb 10; 23(2):380. doi: 10.3390/molecules23020380" |
