| Title: | "The LINA cohort: indoor chemical exposure, circulating eosinophil/basophil (Eo/B) progenitors and early life skin manifestations" |
| Author(s): | Weisse K; Lehmann I; Heroux D; Kohajda T; Herberth G; Roder S; von Bergen M; Borte M; Denburg J; |
| Address: | "Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany" |
| DOI: | 10.1111/j.1365-2222.2012.04024.x |
| ISSN/ISBN: | 1365-2222 (Electronic) 0954-7894 (Linking) |
| Abstract: | "BACKGROUND: Hematopoietic progenitor cells, especially those committed to the Eo/B lineage, are known to contribute to allergic inflammation. OBJECTIVE: The aim of the present study was to investigate whether environmental factors are associated with changes in numbers of circulating Eo/B progenitors at 1 year of age. METHODS: Peripheral blood from 60 1-year-old children enrolled in the LINA (Lifestyle and environmental factors and their Influence on Newborns Allergy risk) birth cohort was assessed for Eo/B progenitor cells (Eo/B CFU) using standardized and validated methylcellulose assays. Frozen peripheral blood mononuclear cells (PBMC) were cultured in the presence of IL-3, IL-5 or GM-CSF, and Eo/B CFUs enumerated. Clinical outcomes and exposure to environmental tobacco smoke (ETS) were documented by standardized questionnaires, and indoor volatile organic compound (VOC) concentrations were assessed by passive sampling. RESULTS: Children with skin manifestations (atopic dermatitis or cradle cap) within the first year of life had higher numbers of circulating IL-3-, IL-5- or GM-CSF-stimulated Eo/B CFUs (P < 0.05) at 1 year. In children with cradle cap, a positive correlation was found between Eo/B CFUs and exposure to ETS-related VOCs during pregnancy or at 1 year of age (P < 0.05). CONCLUSIONS AND CLINICAL RELEVANCE: This is the first demonstration that environmental exposures are positively associated with levels of circulating Eo/B progenitors. The recruitment and differentiation of Eo/B progenitors in response to environmental triggers may play a role in the development of skin manifestations during the first year of life" |
| Keywords: | "Adult Air Pollution, Indoor/*adverse effects *Basophils/immunology Cohort Studies Dermatitis, Atopic/*epidemiology/etiology/immunology Dermatitis, Seborrheic/*epidemiology/immunology Environmental Exposure *Eosinophils/immunology Female *Hematopoietic Ste;" |
| Notes: | "MedlineWeisse, K Lehmann, I Heroux, D Kohajda, T Herberth, G Roder, S von Bergen, M Borte, M Denburg, J eng Research Support, Non-U.S. Gov't England 2012/08/29 Clin Exp Allergy. 2012 Sep; 42(9):1337-46. doi: 10.1111/j.1365-2222.2012.04024.x" |
