| Title: | Cryogenic oven-trapping gas chromatography for analysis of volatile organic compounds in body fluids |
| Author(s): | Watanabe-Suzuki K; Ishii A; Suzuki O; |
| Address: | "Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. kanako@hama-med.ac.jp" |
| DOI: | 10.1007/s00216-002-1240-z |
| ISSN/ISBN: | 1618-2642 (Print) 1618-2642 (Linking) |
| Abstract: | "Cryogenic oven-trapping (COT) with capillary GC has been successfully applied to analysis of chloroform, dichloromethane, trichloroethylene, diethyl ether, the components of solvent thinner (ethyl acetate, benzene, n-butanol, toluene, and others), xylene isomers, cyanide, ethanol, hexanes, general anesthetics, and styrene in human body fluids. This COT-GC technique was compared with headspace solid-phase microextraction (SPME) coupled with GC for some volatile organic compounds (VOC); for all compounds compared the sensitivity achieved using COT-GC was more than ten times higher than for headspace SPME-GC. The COT-GC method is recommended for widespread use in forensic and environmental toxicology, because it is simple, requires no special GC operations, and yet enables high sensitivity and high resolution" |
| Keywords: | "Body Fluids/*chemistry Chromatography, Gas/instrumentation/methods Equipment Design Freezing Humans Organic Chemicals/*analysis;" |
| Notes: | "MedlineWatanabe-Suzuki, K Ishii, A Suzuki, O eng Germany 2002/05/16 Anal Bioanal Chem. 2002 May; 373(1-2):75-80. doi: 10.1007/s00216-002-1240-z. Epub 2002 Feb 19" |
