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Neuroscience

Title:		The effects of local inhibition of N-methyl-D-aspartate and AMPA/kainate receptors in the accessory olfactory bulb on the formation of an olfactory memory in mice
Author(s):		Brennan PA;
Address:		"Sub-Department of Animal Behaviour, University of Cambridge, U.K"
Journal Title:		Neuroscience
Year:		1994
Volume:		60
Issue:		3
Page Number:		701 - 708
DOI:		10.1016/0306-4522(94)90498-7
ISSN/ISBN:		0306-4522 (Print) 0306-4522 (Linking)
Abstract:		"Female mice form a memory to the pheromones of the mating male, during a critical period after mating. Previous experiments have shown that this memory is located in the accessory olfactory bulb and most likely involves changes at the mitral/granule cell reciprocal synapse. Memory formation can be prevented by local infusions of a non-selective ionotropic glutamate receptor antagonist. However, selective antagonism of N-methyl-D-aspartate receptors during the critical period did not disrupt the memory. The present study shows that memory formation is not prevented by local infusions of the AMPA/kainate receptor antagonist 6,7-dinitroquinoxaline-2,3-dione. Thus, it appears that the formation of a memory to the mating male can occur via both N-methyl-D-aspartate receptor-dependent and independent mechanisms. Far from preventing memory formation, local infusions of 6,7-dinitroquinoxaline-2,3-dione resulted in the formation of a non-selective 'memory' to unfamiliar male pheromones. In addition, local infusions of 6,7-dinitroquinoxaline-2,3-dione during pheromonal exposure alone resulted in memory formation without mating having occurred. These results suggest that activity via N-methyl-D-aspartate receptors might be more effective in promoting the synaptic changes underlying memory formation, than activity via AMPA/kainate receptors"
Keywords:		"2-Amino-5-phosphonovalerate/pharmacology Animals Female Fetal Resorption/physiopathology *Long-Term Potentiation Male Memory/*physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Olfactory Bulb/*physiology Pheromones/*physiology Quinoxalines/pharmacolog;neuroscience;"
Notes:		"MedlineBrennan, P A eng Research Support, Non-U.S. Gov't 1994/06/01 Neuroscience. 1994 Jun; 60(3):701-8. doi: 10.1016/0306-4522(94)90498-7"