| Title: | Confounding effect of benign pulmonary diseases in selecting volatile organic compounds as markers of lung cancer |
| Author(s): | Wang M; Sheng J; Wu Q; Zou Y; Hu Y; Ying K; Wan H; Wang P; |
| Address: | "Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, People's Republic of China. State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Lung cancer (LC) is a leading cause of cancer-related morbidity and mortality globally, and exhaled breath testing has been considered as a fast, convenient and non-invasive way to diagnose LC in its early stages. Volatile organic compounds (VOCs), as markers of LC in exhaled breath, have been widely investigated for cancer diagnosis. However, few studies have reported on the interference of benign pulmonary diseases (BPD) in the selection of VOC markers for LC. During this study, 207 samples were analyzed using thermal desorption instrumentation/gas chromatography/mass spectrometry (TD-GCMS) to detect C(6)-C(30) VOCs, and all samples were divided into four groups: LC group, BPD group, lung disease (LD) group (including LC group and BPD group) and healthy group. To make up for the deficiency of detecting low carbon hydrocarbons ( |
| Keywords: | "Biomarkers, Tumor/*analysis Body Fluids/chemistry Breath Tests Case-Control Studies Confounding Factors, Epidemiologic Exhalation Female Gas Chromatography-Mass Spectrometry Humans Lung Diseases/*diagnosis Lung Neoplasms/*diagnosis/*epidemiology Male Midd;" |
| Notes: | "MedlineWang, Min Sheng, Jiajing Wu, Qian Zou, Yingchang Hu, Yanjie Ying, Kejing Wan, Hao Wang, Ping eng Research Support, Non-U.S. Gov't England 2018/08/14 J Breath Res. 2018 Sep 14; 12(4):046013. doi: 10.1088/1752-7163/aad9cc" |
