| Title: | Characterization of chemical transport in human skin and building material |
| Author(s): | Wang H; Wang H; Wang K; Xiong J; Huang S; Wolfson JM; Koutrakis P; |
| Address: | "School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, China. School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, China. Electronic address: xiongjy@bit.edu.cn. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston 02115, United States. Electronic address: shhuang@hsph.harvard.edu. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston 02115, United States" |
| DOI: | 10.1016/j.jhazmat.2023.131917 |
| ISSN/ISBN: | 1873-3336 (Electronic) 0304-3894 (Linking) |
| Abstract: | "Volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) are ubiquitous in indoor environment. They can emit from source into air, and subsequently penetrate human skin into blood through dermal uptake, causing adverse health effects. This study develops a two-layer analytical model to characterize the VOC/SVOC dermal uptake process, which is then extended to predict VOC emissions from two-layer building materials or furniture. Based on the model, the key transport parameters of chemicals in every skin or material layer are determined via a hybrid optimization method using data from experiments and literature. The measured key parameters of SVOCs for dermal uptake are more accurate than those from previous studies using empirical correlations. Moreover, the association between the absorption amount of studied chemicals into blood and age is preliminarily investigated. Further exposure analysis reveals that the contribution of dermal uptake to the total exposure can be comparable with that of inhalation for the examined SVOCs. This study makes the first attempt to accurately determine the key parameters of chemicals in skin, which is demonstrated to be critical for health risk assessment" |
| Keywords: | "Humans *Volatile Organic Compounds/analysis *Air Pollution, Indoor/analysis *Air Pollutants/analysis Skin Construction Materials Dermal uptake Exposure Human skin Semi-volatile organic compounds Volatile organic compounds;" |
| Notes: | "MedlineWang, Hao Wang, Haimei Wang, Keliang Xiong, Jianyin Huang, Shaodan Wolfson, Jack M Koutrakis, Petros eng Research Support, Non-U.S. Gov't Netherlands 2023/06/28 J Hazard Mater. 2023 Sep 15; 458:131917. doi: 10.1016/j.jhazmat.2023.131917. Epub 2023 Jun 22" |
