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Regul Toxicol Pharmacol

Title:		An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion
Author(s):		Wagner KA; Flora JW; Melvin MS; Avery KC; Ballentine RM; Brown AP; McKinney WJ;
Address:		"Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA. Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA. Electronic address: Jason.W.Flora@altria.com"
Journal Title:		Regul Toxicol Pharmacol
Year:		2018
Volume:		20180320
Issue:
Page Number:		153 - 160
DOI:		10.1016/j.yrtph.2018.03.012
ISSN/ISBN:		1096-0295 (Electronic) 0273-2300 (Linking)
Abstract:		"U.S. FDA draft guidance recommends reporting quantities of designated harmful and potentially harmful constituents (HPHCs) in e-cigarette e-liquids and aerosols. The HPHC list comprises potential matrix-related compounds, flavors, nicotine, tobacco-related impurities, leachables, thermal degradation products, and combustion-related compounds. E-cigarettes contain trace levels of many of these constituents due to tobacco-derived nicotine and thermal degradation. However, combustion-related HPHCs are not likely to be found due to the relatively low operating temperatures of most e-cigarettes. The purpose of this work was to use highly sensitive, selective, and validated analytical methods to determine if these combustion-related HPHCs (three aromatic amines, five volatile organic compounds, and the polycyclic aromatic hydrocarbon benzo[a]pyrene) are detectable in commercial refill e-liquids, reference e-cigarette e-liquids, and aerosols generated from rechargeable e-cigarettes with disposable cartridges (often referred to as 'cig-a-likes'). In addition, the transfer efficiency of these constituents from e-liquid to aerosol was evaluated when these HPHCs were added to the e-liquids prior to aerosol formation. This work demonstrates that combustion-related HPHCs are not present at measurable levels in the commercial and reference e-liquids or e-cigarette aerosols tested. Additionally, when combustion-related HPHCs are added to the e-liquids, they transfer to the aerosol with transfer efficiencies ranging from 49% to 99%"
Keywords:		Aerosols Benzo(a)pyrene/*analysis *Electronic Nicotine Delivery Systems Hazardous Substances/*analysis Volatile Organic Compounds/*analysis Combustion E-cigarette E-liquid Ends Hphc Harmful and potentially harmful constituents;
Notes:		"MedlineWagner, Karl A Flora, Jason W Melvin, Matt S Avery, Karen C Ballentine, Regina M Brown, Anthony P McKinney, Willie J eng Netherlands 2018/03/24 Regul Toxicol Pharmacol. 2018 Jun; 95:153-160. doi: 10.1016/j.yrtph.2018.03.012. Epub 2018 Mar 20"