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Nat Commun

Title:		Aggregation pheromones have a non-linear effect on oviposition behavior in Drosophila melanogaster
Author(s):		Verschut TA; Ng R; Doubovetzky NP; Le Calvez G; Sneep JL; Minnaard AJ; Su CY; Carlsson MA; Wertheim B; Billeter JC;
Address:		"Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands. Department of Zoology, Stockholm University, 106 91, Stockholm, Sweden. Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands. Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands. j.c.billeter@rug.nl"
Journal Title:		Nat Commun
Year:		2023
Volume:		20230320
Issue:		1
Page Number:		1544 -
DOI:		10.1038/s41467-023-37046-2
ISSN/ISBN:		2041-1723 (Electronic) 2041-1723 (Linking)
Abstract:		"Female fruit flies (Drosophila melanogaster) oviposit at communal sites where the larvae may cooperate or compete for resources depending on group size. This offers a model system to determine how females assess quantitative social information. We show that the concentration of pheromones found on a substrate increases linearly with the number of adult flies that have visited that site. Females prefer oviposition sites with pheromone concentrations corresponding to an intermediate number of previous visitors, whereas sites with low or high concentrations are unattractive. This dose-dependent decision is based on a blend of 11-cis-Vaccenyl Acetate (cVA) indicating the number of previous visitors and heptanal (a novel pheromone deriving from the oxidation of 7-Tricosene), which acts as a dose-independent co-factor. This response is mediated by detection of cVA by odorant receptor neurons Or67d and Or65a, and at least five different odorant receptor neurons for heptanal. Our results identify a mechanism allowing individuals to transform a linear increase of pheromones into a non-linear behavioral response"
Keywords:		"Animals Female Drosophila melanogaster/physiology *Drosophila Proteins *Receptors, Odorant Oviposition Pheromones Drosophila Sexual Behavior, Animal/physiology;"
Notes:		"MedlineVerschut, Thomas A Ng, Renny Doubovetzky, Nicolas P Le Calvez, Guillaume Sneep, Jan L Minnaard, Adriaan J Su, Chih-Ying Carlsson, Mikael A Wertheim, Bregje Billeter, Jean-Christophe eng Research Support, Non-U.S. Gov't England 2023/03/22 Nat Commun. 2023 Mar 20; 14(1):1544. doi: 10.1038/s41467-023-37046-2"