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Environ Res

Title:		Nasal lavages as a tool for monitoring exposure to organic pollutants
Author(s):		Velazquez-Gomez M; Lacorte S;
Address:		"Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain. Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain. Electronic address: slbqam@cid.csic.es"
Journal Title:		Environ Res
Year:		2019
Volume:		20190906
Issue:
Page Number:		108726 -
DOI:		10.1016/j.envres.2019.108726
ISSN/ISBN:		1096-0953 (Electronic) 0013-9351 (Linking)
Abstract:		"Exposure to air and dust pollutants can cause several adverse effects on human health. This study proposes the use of nasal lavages as a non-invasive sampling technique to determine in a direct way pollutant intake through inhalation. We evaluate the occurrence of compounds widely used in domestic products and construction materials (organophosphorus flame retardants (OPFR), phthalates, alkylphenols and bisphenol A), applied for pest control in cities (pesticides) and emitted through car exhausts (polycyclic aromatic hydrocarbons, PAHs) or smoking (nicotine). Contaminants were liquid-liquid extracted from nasal lavages and analysed using gas chromatography coupled to tandem mass spectrometry (GC-MS/MS). All 29 individuals inhabiting in Barcelona city had phthalates and bisphenol A at concentrations up to 31,300?ª+ng?ª+mL(-1) for diethylhexyl phthalate (DEHP) and 118?ª+ng?ª+mL(-1) for BPA. Individual PAHs, OPFR and alkylphenols had median values below their MQLs except for 2-ethylhexyldiphenyl phosphate (EHDPhP) with a median of 1.47?ª+ng?ª+mL(-1). Nicotine was detected at the highest concentrations in all active smokers (median 2.16?ª+ng?ª+mL(-1)). Contrarily, pesticides were sporadically detected. Nasal lavages revealed to be an appropriate indicator likely to reflect exposure to dust and air contaminants"
Keywords:		Cities Environmental Exposure/*statistics & numerical data Environmental Monitoring Environmental Pollutants/*metabolism Gas Chromatography-Mass Spectrometry Humans Nasal Lavage/*methods Polycyclic Aromatic Hydrocarbons/*metabolism Tandem Mass Spectrometr;
Notes:		"MedlineVelazquez-Gomez, Miguel Lacorte, Silvia eng Research Support, Non-U.S. Gov't Netherlands 2019/09/21 Environ Res. 2019 Nov; 178:108726. doi: 10.1016/j.envres.2019.108726. Epub 2019 Sep 6"