| Title: | Exhaled volatile organic compounds detect pulmonary exacerbations early in children with cystic fibrosis: results of a 1 year observational pilot study |
| Author(s): | van Horck M; Smolinska A; Wesseling G; de Winter-de Groot K; de Vreede I; Winkens B; Jobsis Q; Dallinga J; Dompeling E; van Schooten FJ; |
| Address: | "Department of Paediatric Pulmonology, School for Public Health and Primary Health Care (CAPHRI), Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "In patients with cystic fibrosis (CF), pulmonary exacerbations (PEx) have an important influence on well-being, quality of life, and lung function decline. Early detection combined with early treatment may prevent severe PEx. To determine whether early detection of PEx is possible by non-invasive markers (volatile organic compounds) in exhaled breath. In a 1 year prospective observational pilot study, 49 children with CF were studied. At clinical visits with an interval of 2 months, lung function, volatile organic compounds (VOCs) in exhaled breath by means of gas chromatography-time-of-flight-mass spectrometry, and medication use were assessed. PEx were recorded. Random forest (RF) classification modelling was used to select discriminatory VOCs, followed by building of receiver operating characteristic curves. An inverse relation between the predictive power of a set of VOCs and time between exhaled breath sampling and the onset of PEx was found. When this time period was within 7 d, the RF model with the nine most discriminatory VOCs was able to correctly predict 79% of the children with an upcoming PEx or remaining stable (sensitivity 79% and specificity 78%). This result was validated by means of bootstrapping within the RF classification model. PEx in children with CF can be detected at an early stage by means of exhaled VOCs. The highest predictive value was reached if time between sampling and the onset of an exacerbation was no longer than 7 d" |
| Keywords: | Breath Tests Child *Cystic Fibrosis/diagnosis Exhalation Humans Lung Pilot Projects Prospective Studies Quality of Life Volatile Organic Compounds; |
| Notes: | "Medlinevan Horck, Marieke Smolinska, Agnieszka Wesseling, Geertjan de Winter-de Groot, Karin de Vreede, Ilja Winkens, Bjorn Jobsis, Quirijn Dallinga, Jan Dompeling, Edward van Schooten, Frederik-Jan eng Observational Study England 2021/02/26 J Breath Res. 2021 Feb 25; 15(2):026012. doi: 10.1088/1752-7163/abda55" |
