| Title: | Multiple genes encoding pheromones and a pheromone receptor define the B beta 1 mating-type specificity in Schizophyllum commune |
| Author(s): | Vaillancourt LJ; Raudaskoski M; Specht CA; Raper CA; |
| Address: | "Department of Microbiology and Molecular Genetics, L. P. Markey Center for Molecular Genetics, University of Vermont, Burlington 05405, USA" |
| DOI: | 10.1093/genetics/146.2.541 |
| ISSN/ISBN: | 0016-6731 (Print) 0016-6731 (Linking) |
| Abstract: | "The genes defining multiple B mating types in the wood-rotting mushroom Schizophyllum commune are predicted to encode multiple pheromones and pheromone receptors. These genes are clustered in each of two recombinable and independently functioning loci, B alpha and B beta. A difference in specificity at either locus between a mated pair of individuals initiates an identical series of events in sexual morphogenesis. The B alpha 1 locus was recently found to contain genes predicted to encode three lipopeptide pheromones and a pheromone receptor with a seven-transmembrane domain. These gene products interact in hetero-specific pairs, the pheromone of one B alpha specificity with the receptor of any one of the other eight B alpha specificities, and are likely to activate a signaling cascade similar to that known for mating in Saccharomyces cerevisiae. We report here that the B beta 1 locus also contains at least three pheromone genes and one pheromone receptor gene, which function similarly to the genes in the B alpha 1 locus, but only within the series of B beta specificities. A comparison of the DNA sequences of the B alpha 1 and B beta 1 loci suggests that each arose from a common ancestral sequence, allowing us to speculate about the evolution of this unique series of regulatory genes" |
| Keywords: | "Amino Acid Sequence Blotting, Northern Blotting, Southern Cell Nucleus/metabolism *Chemoreceptor Cells/chemistry/metabolism Cloning, Molecular Evolution, Molecular *Genes, Fungal *Genes, Mating Type, Fungal Molecular Sequence Data Pheromones/chemistry/*ge;" |
| Notes: | "MedlineVaillancourt, L J Raudaskoski, M Specht, C A Raper, C A eng CA-1405/CA/NCI NIH HHS/ GM-31318/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 1997/06/01 Genetics. 1997 Jun; 146(2):541-51. doi: 10.1093/genetics/146.2.541" |
